Kumar Ajay, Chugani Harry T
PET Center, Department of Pediatrics, Neurology, and Radiology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan
PET Center, Department of Pediatrics, Neurology, and Radiology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan.
J Nucl Med Technol. 2017 Mar;45(1):22-29. doi: 10.2967/jnumed.113.129593.
PET and SPECT can play an important role in the evaluation of various epileptic syndromes, particularly those with unknown causes, by revealing various underlying abnormalities that may not be fully appreciated from MR imaging studies. In some cases, PET and SPECT provide crucial data that guide surgical resections of the epileptogenic zone for medically refractory epilepsy. In other cases, these neuroimaging modalities preclude a surgical option and can guide genetic studies. Longitudinal PET and SPECT studies may increase our understanding of the etiopathogenesis of epilepsy syndromes and provide a clearer picture of the natural history of neurologic progression.
正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）在评估各种癫痫综合征，尤其是病因不明的癫痫综合征方面可发挥重要作用，它们能揭示一些磁共振成像（MR）研究可能无法完全发现的潜在异常。在某些情况下，PET和SPECT提供的关键数据可指导对药物难治性癫痫的致痫区进行手术切除。在其他情况下，这些神经影像学检查方法可排除手术选择，并能指导基因研究。PET和SPECT的纵向研究可能会增进我们对癫痫综合征病因发病机制的理解，并更清晰地呈现神经进展的自然病程。
