PET Center, Department of Pediatrics, Neurology, and Radiology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan.
J Nucl Med. 2013 Nov;54(11):1924-30. doi: 10.2967/jnumed.113.129593. Epub 2013 Sep 12.
PET and SPECT can play an important role in the evaluation of various epileptic syndromes, particularly those with unknown causes, by revealing various underlying abnormalities that may not be fully appreciated from MR imaging studies. In some cases, PET and SPECT provide crucial data that guide surgical resections of the epileptogenic zone for medically refractory epilepsy. In other cases, these neuroimaging modalities preclude a surgical option and can guide genetic studies. Longitudinal PET and SPECT studies may increase our understanding of the etiopathogenesis of epilepsy syndromes and provide a clearer picture of the natural history of neurologic progression.
PET 和 SPECT 在评估各种癫痫综合征中具有重要作用，特别是对那些病因不明的病例，可以揭示磁共振成像研究可能未充分显示的各种潜在异常。在某些情况下，PET 和 SPECT 提供了关键数据，可指导对药物难治性癫痫进行致痫灶的手术切除。在其他情况下，这些神经影像学方法排除了手术选择，并可指导基因研究。纵向 PET 和 SPECT 研究可能会增加我们对癫痫综合征病因发病机制的理解，并更清楚地了解神经进展的自然史。
