Kumar Ajay, Chugani Harry T
PET Center, Department of Pediatrics, Neurology, and Radiology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan
PET Center, Department of Pediatrics, Neurology, and Radiology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan.
J Nucl Med Technol. 2017 Mar;45(1):14-21. doi: 10.2967/jnumed.112.114397.
Epilepsy is one of the most common yet diverse neurologic disorders, affecting almost 1%-2% of the population. Presently, radionuclide imaging such as PET and SPECT is not used in the primary diagnosis or evaluation of recent-onset epilepsy. However, it can play a unique and important role in certain specific situations, such as in noninvasive presurgical localization of epileptogenic brain regions in intractable-seizure patients being considered for epilepsy surgery. Radionuclide imaging can be particularly useful if MR imaging is either negative for lesions or shows several lesions of which only 1 or 2 are suspected to be epileptogenic and if electroencephalogram changes are equivocal or discordant with the structural imaging. Similarly, PET and SPECT can also be useful for evaluating the functional integrity of the rest of the brain and may provide useful information on the possible pathogenesis of the neurocognitive and behavioral abnormalities frequently observed in these patients.
癫痫是最常见且多样的神经系统疾病之一，影响着近1%-2%的人口。目前，正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）等放射性核素成像未用于新发癫痫的初步诊断或评估。然而，它在某些特定情况下可发挥独特且重要的作用，例如在考虑进行癫痫手术的难治性癫痫患者中，用于癫痫源脑区的无创术前定位。如果磁共振成像（MR）未发现病变或显示多个病变但仅怀疑其中1个或2个为癫痫源，且脑电图变化不明确或与结构成像不一致，放射性核素成像可能特别有用。同样，PET和SPECT也可用于评估大脑其他部分的功能完整性，并可能为这些患者中经常观察到的神经认知和行为异常的可能发病机制提供有用信息。
