da Silva Inês Vieira, Soveral Graça
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, 1649-003, Portugal.
Department of Bioquimica e Biologia Humana, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Adv Exp Med Biol. 2017;969:227-238. doi: 10.1007/978-94-024-1057-0_15.
Obesity is one of the most important metabolic disorders of this century and is associated with a cluster of the most dangerous cardiovascular disease risk factors, such as insulin resistance and diabetes , dyslipidemia and hypertension , collectively named Metabolic Syndrome. The role of aquaporins in glycerol metabolism facilitating glycerol release from the adipose tissue and distribution to various tissues and organs, unveils these membrane channels as important players in lipid balance and energy homeostasis and points to their involvement in a variety of pathophysiological mechanisms including insulin resistance, obesity and diabetes.This review summarizes the physiologic role of aquaglyceroporins in glycerol metabolism and lipid homeostasis, describing their specific tissue distribution, their involvement in glycerol balance and their implication in obesity and fat-related metabolic complications. The development of specify pharmacologic modulators able to regulate aquaglyceroporins expression and function , in particular AQP7 in adipose tissue, might constitute a novel approach for controlling obesity and other metabolic disorders.
肥胖是本世纪最重要的代谢紊乱之一，与一系列最危险的心血管疾病风险因素相关，如胰岛素抵抗和糖尿病、血脂异常和高血压，统称为代谢综合征。水通道蛋白在甘油代谢中促进甘油从脂肪组织释放并分布到各种组织和器官，揭示了这些膜通道在脂质平衡和能量稳态中是重要参与者，并表明它们参与了包括胰岛素抵抗、肥胖和糖尿病在内的多种病理生理机制。本综述总结了水甘油通道蛋白在甘油代谢和脂质稳态中的生理作用，描述了它们的特定组织分布、它们在甘油平衡中的作用以及它们在肥胖和脂肪相关代谢并发症中的影响。开发能够调节水甘油通道蛋白表达和功能的特定药理调节剂，特别是脂肪组织中的水通道蛋白7，可能构成一种控制肥胖和其他代谢紊乱的新方法。
