Division of Molecular Medicine, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia.
Molecules. 2021 Apr 29;26(9):2613. doi: 10.3390/molecules26092613.
Breast cancer is still one of the leading causes of mortality in the female population. Despite the campaigns for early detection, the improvement in procedures and treatment, drastic improvement in survival rate is omitted. Discovery of aquaporins, at first described as cellular plumbing system, opened new insights in processes which contribute to cancer cell motility and proliferation. As we discover new pathways activated by aquaporins, the more we realize the complexity of biological processes and the necessity to fully understand the pathways affected by specific aquaporin in order to gain the desired outcome-remission of the disease. Among the 13 human aquaporins, AQP3 and AQP5 were shown to be significantly upregulated in breast cancer indicating their role in the development of this malignancy. Therefore, these two aquaporins will be discussed for their involvement in breast cancer development, regulation of oxidative stress and redox signalling pathways leading to possibly targeting them for new therapies.
乳腺癌仍然是女性人群中主要的致死原因之一。尽管开展了早期检测活动，改进了操作和治疗方法，但生存率仍未得到显著提高。水通道蛋白的发现最初被描述为细胞管道系统，为促进癌细胞迁移和增殖的过程提供了新的见解。随着我们发现水通道蛋白激活的新途径，我们越来越意识到生物过程的复杂性，以及有必要充分了解受特定水通道蛋白影响的途径，以获得预期的结果——疾病缓解。在 13 个人类水通道蛋白中，AQP3 和 AQP5 在乳腺癌中显著上调，表明它们在这种恶性肿瘤的发展中起作用。因此，将讨论这两种水通道蛋白在乳腺癌发展中的作用、调节氧化应激和氧化还原信号通路，以可能将它们作为新疗法的靶点。
