Elloudi S, Gallouj S, Meziane M, Mernissi F-Z, Rimani M
Service de dermatologie-vénérologie, CHU Hassan II, route Sidi-Hrazem, Fès, Maroc.
Service de dermatologie-vénérologie, CHU Hassan II, route Sidi-Hrazem, Fès, Maroc.
Ann Dermatol Venereol. 2017 Jun-Jul;144(6-7):409-414. doi: 10.1016/j.annder.2017.01.014. Epub 2017 Mar 1.
Frontal fibrosing alopecia (FFA) is a variant of lichen planopilaris predominantly affecting postmenopausal women. We report a series of 20 cases of FFA and describe the epidemiological, clinical, dermoscopic features and progress under treatment.
This was a prospective study conducted over a period of 16 months in patients seen at the dermatology department of the Hassan II University in Fez, Morocco.
Mean patient age was 46 years. Patients were premenopausal in 65% of cases. Dermoscopic examination revealed specific signs of the disease. Skin biopsy guided by dermoscopy confirmed the diagnosis of lichen planus pilaris in its FFA variant in all cases. Immune dysfunctions and other disorders were noted in half of the cases. Various treatments had been initiated, including topical corticosteroids, tacrolimus ointment, minoxidil 2%, hydroxychloroquine, and oral finasteride. The results were satisfactory with a decline within one year.
FFA is increasingly widely described in premenopausal women. Dermoscopy may be used to facilitate diagnosis, guide biopsy, evaluate treatment efficacy and establish a prognosis.
额部纤维性秃发（FFA）是扁平苔藓性毛发角化病的一种变体，主要影响绝经后女性。我们报告了一系列20例FFA病例，并描述了其流行病学、临床、皮肤镜特征及治疗进展。
这是一项在摩洛哥非斯哈桑二世大学皮肤科对患者进行的为期16个月的前瞻性研究。
患者平均年龄为46岁。65%的病例处于绝经前。皮肤镜检查揭示了该病的特异性体征。在皮肤镜引导下进行的皮肤活检在所有病例中均确诊为FFA变体的扁平苔藓性毛发角化病。半数病例存在免疫功能障碍及其他病症。已启动多种治疗，包括外用糖皮质激素、他克莫司软膏、2%米诺地尔、羟氯喹及口服非那雄胺。结果令人满意，一年内病情有所缓解。
FFA在绝经前女性中的报道日益广泛。皮肤镜可用于辅助诊断、指导活检、评估治疗效果及判断预后。
