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BAIAP2L2 是一种与 HCC 迁移和侵袭相关的新型预后生物标志物，与铜死亡有关。

BAIAP2L2 is a novel prognostic biomarker related to migration and invasion of HCC and associated with cuprotosis.

机构信息

The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, China.

Department of Gastroenterology, Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, 730000, Gansu Province, China.

出版信息

Sci Rep. 2023 May 29;13(1):8692. doi: 10.1038/s41598-023-35420-0.

DOI:10.1038/s41598-023-35420-0
PMID:37248248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10227027/
Abstract

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and its pathophysiological mechanisms remain unknown. IRSp53 family members, such as BAIAP2L1, participate in the progression of multiple tumors. However, the role of BAIAP2L2 in HCC remains unclear. This study comprehensively analyzed the potential role of BAIAP2L2 in HCC using bioinformatic techniques. The expression of BAIAP2L2 in HCC was analyzed using The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), International Cancer Genome Consortium (ICGC), and Human Protein Atlas (HPA) databases and in vitro experiments. In addition, the prognostic value of BAIAP2L2 in HCC was analyzed using the TCGA database. TCGA and GEO database were used to analyze the role of BAIAP2L2 in immune features. We also explored the function of BAIAP2L2 in methylation and cuprotosis. The CellMiner database was used to analyze the relationship between BAIAP2L2 expression and drug sensitivity. Our study revealed that BAIAP2L2 is overexpressed in HCC and promotes the migration and invasion of HCC cells. BAIAP2L2 may affect the prognosis of HCC by regulating immunity, methylation, and cuprotosis. BAIAP2L2 is a novel HCC prognostic gene involved in immune infiltration associated with cuprotosis and may be a potential prognosis and therapeutic target for HCC.

摘要

肝细胞癌 (HCC) 是全球癌症相关死亡的主要原因，但其病理生理机制尚不清楚。IRSp53 家族成员，如 BAIAP2L1，参与多种肿瘤的进展。然而，BAIAP2L2 在 HCC 中的作用尚不清楚。本研究综合利用生物信息学技术分析了 BAIAP2L2 在 HCC 中的潜在作用。利用癌症基因组图谱 (TCGA)、基因表达综合 (GEO)、国际癌症基因组联合会 (ICGC) 和人类蛋白质图谱 (HPA) 数据库以及体外实验分析了 HCC 中 BAIAP2L2 的表达。此外，还利用 TCGA 数据库分析了 BAIAP2L2 在 HCC 中的预后价值。TCGA 和 GEO 数据库用于分析 BAIAP2L2 在免疫特征中的作用。我们还探讨了 BAIAP2L2 在甲基化和铜死亡中的功能。CellMiner 数据库用于分析 BAIAP2L2 表达与药物敏感性的关系。我们的研究表明，BAIAP2L2 在 HCC 中过表达，并促进 HCC 细胞的迁移和侵袭。BAIAP2L2 可能通过调节免疫、甲基化和铜死亡来影响 HCC 的预后。BAIAP2L2 是一种新型 HCC 预后基因，与铜死亡相关的免疫浸润有关，可能是 HCC 的潜在预后和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/1ca201fcabcf/41598_2023_35420_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/8891997fe551/41598_2023_35420_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/ff353de9fc66/41598_2023_35420_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/88581746c182/41598_2023_35420_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/e644340766ed/41598_2023_35420_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/f9fd569a578d/41598_2023_35420_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/943a375560e7/41598_2023_35420_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/7b954f73c22a/41598_2023_35420_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/31b6c8c38e6e/41598_2023_35420_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/1ca201fcabcf/41598_2023_35420_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/8891997fe551/41598_2023_35420_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/ff353de9fc66/41598_2023_35420_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/88581746c182/41598_2023_35420_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/e644340766ed/41598_2023_35420_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/f9fd569a578d/41598_2023_35420_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/943a375560e7/41598_2023_35420_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/7b954f73c22a/41598_2023_35420_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/31b6c8c38e6e/41598_2023_35420_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6170/10227027/1ca201fcabcf/41598_2023_35420_Fig9_HTML.jpg

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