Reinfection of guinea pigs with herpes simplex virus type 2: failure to establish a second latent ganglionic infection.

Guinea pigs were infected with herpes simplex virus type 2 (HSV 2) and at various times thereafter reinfected at a different site with the same or a different strain of HSV 2. Viruses were isolated from infected tissues either from the site of primary or secondary infection or from regional ganglia. Viral isolates were characterised by DNA fingerprinting using restriction endonucleases capable of differentiating between the virus strains used. The second infection resulted in a second site of peripheral persistence of the virus, but did not establish a second site of ganglionic infection.