• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

豚鼠复发性生殖器单纯疱疹病毒（HSV）感染

Recurrent genital Herpes simplex virus (HSV) infection of guinea pigs.

作者信息

Scriba M

出版信息

Med Microbiol Immunol. 1976 Dec 1;162(3-4):201-8. doi: 10.1007/BF02120998.

DOI:10.1007/BF02120998
PMID:187918
Abstract

Intravaginal infection of guinea pigs with HSV type 2 induced lesions resembling genital herpes in humans. Chronic latent infection with spontaneously recurring genital lesions developed in animals surviving the primary disease. Clinical observations and virological studies during the acute and chronic infection are reported.

摘要

用2型单纯疱疹病毒对豚鼠进行阴道内感染，可诱发类似人类生殖器疱疹的损伤。在原发性疾病中存活下来的动物会发展为慢性潜伏感染，并伴有生殖器损伤的自发复发。本文报告了急性和慢性感染期间的临床观察和病毒学研究情况。

相似文献

1
Recurrent genital Herpes simplex virus (HSV) infection of guinea pigs.豚鼠复发性生殖器单纯疱疹病毒（HSV）感染
Med Microbiol Immunol. 1976 Dec 1;162(3-4):201-8. doi: 10.1007/BF02120998.
2
Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease.豚鼠生殖器疱疹：原发性感染的发病机制及复发性疾病的描述。
J Infect Dis. 1982 Sep;146(3):397-404. doi: 10.1093/infdis/146.3.397.
3
Persistence of herpes simplex virus (HSV) infection in ganglia and peripheral tissues of guinea pigs.单纯疱疹病毒（HSV）在豚鼠神经节和外周组织中的持续性感染。
Med Microbiol Immunol. 1981;169(2):91-6. doi: 10.1007/BF02171776.
4
Extraneural localisation of herpes simplex virus in latently infected guinea pigs.
Nature. 1977 Jun 9;267(5611):529-31. doi: 10.1038/267529a0.
5
Zosteriform spread of herpes simplex virus type 2 genital infection in the guinea-pig.豚鼠中2型单纯疱疹病毒生殖器感染的带状疱疹样扩散。
J Gen Virol. 1986 Sep;67 ( Pt 9):1851-7. doi: 10.1099/0022-1317-67-9-1851.
6
Effect of phosphonoformate on symptomatic genital herpes simplex virus type 2 infection of guinea pigs.膦甲酸钠对豚鼠有症状的2型单纯疱疹病毒生殖器感染的影响。
Intervirology. 1983;19(1):26-32. doi: 10.1159/000149333.
7
Recurrent genital herpes simplex virus infection in guinea pigs.豚鼠复发性单纯疱疹病毒生殖器感染
Intervirology. 1985;24(4):226-31. doi: 10.1159/000149647.
8
Herpes genitalis in guinea-pigs. I. Kinetic study in infection with Herpesvirus hominis type 2.豚鼠的生殖器疱疹。I. 人疱疹病毒2型感染的动力学研究。
Arch Virol. 1975;41(1):1-11. doi: 10.1007/BF02175590.
9
Herpes genitalis in guinea-pigs. II. Morphological studies in female guinea-pigs infected with Herpesvirus hominis type 2.豚鼠的生殖器疱疹。II. 感染2型人疱疹病毒的雌性豚鼠的形态学研究。
Arch Virol. 1975;49(1):13-24. doi: 10.1007/BF02175591.
10
Herpes simplex virus infection in guinea pigs: an animal model for studying latent and recurrent herpes simplex virus infection.豚鼠单纯疱疹病毒感染：一种用于研究单纯疱疹病毒潜伏和复发感染的动物模型。
Infect Immun. 1975 Jul;12(1):162-5. doi: 10.1128/iai.12.1.162-165.1975.

引用本文的文献

1
Animal models of human herpesvirus infection.人类疱疹病毒感染的动物模型。
Animal Model Exp Med. 2025 Apr;8(4):615-628. doi: 10.1002/ame2.12575. Epub 2025 Feb 7.
2
Guinea Pig and Mouse Models for Genital Herpes Infection.豚鼠和小鼠的生殖器疱疹感染模型。
Curr Protoc. 2021 Dec;1(12):e332. doi: 10.1002/cpz1.332.
3
Use of the Guinea pig model of genital herpes to evaluate vaccines and antivirals: Review.生殖器疱疹豚鼠模型在疫苗和抗病毒药物评价中的应用：综述。

本文引用的文献

1
Hepres genitalis; clinical and cytopathologic experience with 256 patients.
Obstet Gynecol. 1970 Oct;36(4):645-51.
2
Recovery of herpes simplex virus from human sacral ganglions.从人骶神经节中分离出单纯疱疹病毒。
N Engl J Med. 1974 Oct 17;291(16):828-30. doi: 10.1056/NEJM197410172911606.
3
Association between herpes hominis type 2 and the male genitourinary tract.
J Urol. 1974 Jul;112(1):126-7. doi: 10.1016/s0022-5347(17)59659-7.
4
Antiviral Res. 2020 Aug;180:104821. doi: 10.1016/j.antiviral.2020.104821. Epub 2020 Jun 13.
4
Rapid host immune response and viral dynamics in herpes simplex virus-2 infection.单纯疱疹病毒 2 感染中的快速宿主免疫反应和病毒动力学。
Nat Med. 2013 Mar;19(3):280-90. doi: 10.1038/nm.3103.
5
HSV-2: in pursuit of a vaccine.单纯疱疹病毒 2 型：追求疫苗。
J Clin Invest. 2011 Dec;121(12):4600-9. doi: 10.1172/JCI57148. Epub 2011 Dec 1.
6
Intravaginal administration of herpes simplex virus type 2 to mice leads to infection of several neural and extraneural sites.对小鼠进行阴道内单纯疱疹病毒2型给药会导致多个神经和神经外部位感染。
J Neurovirol. 2003 Dec;9(6):594-602. doi: 10.1080/13550280390246499.
7
Criteria for development of animal models of diseases of the reproductive system.生殖系统疾病动物模型的建立标准。
Am J Pathol. 1980 Dec;101(3 Suppl):S241-53.
8
Efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine against primary and recrudescent genital herpes simplex virus type 2 infections in guinea pigs.无环核苷9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤对豚鼠原发性和复发性2型单纯疱疹病毒生殖器感染的疗效。
Antimicrob Agents Chemother. 1983 Dec;24(6):883-7. doi: 10.1128/AAC.24.6.883.
9
Pathogenesis of Herpes simplex virus infections in guinea pigs.豚鼠单纯疱疹病毒感染的发病机制
Infect Immun. 1981 Dec;34(3):655-61. doi: 10.1128/iai.34.3.655-661.1981.
10
Interaction of herpesvirus with spleen cell subpopulations comparison of a neurotropic and a lymphotropic virus.疱疹病毒与脾细胞亚群的相互作用：嗜神经病毒和嗜淋巴细胞病毒的比较
Infect Immun. 1980 Dec;30(3):678-85. doi: 10.1128/iai.30.3.678-685.1980.
Genital herpes in guinea-pigs. An experimental model with Herpesvirus hominis.
Arch Gesamte Virusforsch. 1974;44(2):153-5. doi: 10.1007/BF01250226.
5
Fatal encephalitis due to Herpesvirus hominis: use of intact brain cells for isolation of virus.
J Infect Dis. 1972 May;125(5):542-4. doi: 10.1093/infdis/125.5.542.
6
Latent herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection.来自患有复发性眼部感染兔子三叉神经节的潜伏单纯疱疹病毒。
Nat New Biol. 1972 Feb 16;235(59):216-7. doi: 10.1038/newbio235216a0.
7
Latent herpes simplex virus in spinal ganglia of mice.小鼠脊髓神经节中的潜伏性单纯疱疹病毒
Science. 1971 Aug 27;173(3999):843-5. doi: 10.1126/science.173.3999.843.
8
Spontaneous reactivation of experimental herpes simplex keratitis in rabbits.兔实验性单纯疱疹性角膜炎的自发再激活
Arch Ophthalmol. 1967 Oct;78(4):523-9. doi: 10.1001/archopht.1967.00980030525021.
9
Latent herpetic infections following experimental viraemia.
J Gen Virol. 1976 Apr;31(1):75-80. doi: 10.1099/0022-1317-31-1-75.
10
Herpes simplex virus infection of nervous tissue in animals and man.动物和人类神经组织的单纯疱疹病毒感染
Prog Med Virol. 1975;20:1-26.