Little Rebecca B, Nabors L Burt, Olson Jeffrey J, Thompson Zachary J, Rozmeski Carrie M, LaRocca Renato V, Forsyth Peter A, Thompson Reid C, Oster Robert A, Chowdhary Sajeel A, Egan Kathleen M
Department of Nutrition Sciences, University of Alabama at Birmingham, Webb 449, 1675 University Blvd., Birmingham, AL, 35294, USA.
Neuro-oncology Program, University of Alabama at Birmingham, FOT 1020, 510 20th St. South, Birmingham, AL, 35294, USA.
Cancer Causes Control. 2017 Jul;28(7):709-716. doi: 10.1007/s10552-017-0871-5. Epub 2017 Mar 4.
To examine the association of age when adult height was attained with glioma risk.
We analyzed data from a US-based case-control study of glioma risk factors. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) associated between age at attainment of adult height and glioma risk. Multivariate models were adjusted for age, race, sex, education, and state of residence. We examined associations overall, and according to glioma grade, sex, and final adult height.
The study set included n = 951 controls and n = 776 cases, with a median age of 56 (18-92); the majority was male (53.8%) and identified as Caucasian. Older age at height completion was associated with an increased risk of glioma. A significant positive trend was observed both for glioblastoma (OR 1.10; 95% CI 1.04-1.17 per 1-year increase in age) and lower grade non-glioblastoma subtypes combined (OR 1.18; 95% CI 1.10-1.28 per year increase in age). The association was observed in men and women, and in all categories of final adult height.
We observed for the first time a positive association between glioma risk and a prolonged adolescent growth phase. Our results suggest a role for factors governing the timing and intensity of growth in adolescence as risk-determining exposures in adult glioma.
研究达到成人身高时的年龄与胶质瘤风险之间的关联。
我们分析了一项基于美国的胶质瘤危险因素病例对照研究的数据。采用逻辑回归来估计达到成人身高时的年龄与胶质瘤风险之间的比值比（OR）和95%置信区间（CI）。多变量模型对年龄、种族、性别、教育程度和居住州进行了调整。我们总体上以及根据胶质瘤分级、性别和最终成人身高来研究关联。
研究样本包括n = 951名对照和n = 776名病例，中位年龄为56岁（18 - 92岁）；大多数为男性（53.8%），且为白种人。身高完成时年龄较大与胶质瘤风险增加相关。对于胶质母细胞瘤（每增加1岁，OR 1.10；95% CI 1.04 - 1.17）和较低级别非胶质母细胞瘤亚型合并（每增加1岁，OR 1.18；95% CI 1.10 - 1.28）均观察到显著的正相关趋势。在男性和女性以及所有最终成人身高类别中均观察到这种关联。
我们首次观察到胶质瘤风险与青春期生长阶段延长之间存在正相关。我们的结果表明，在成人胶质瘤中，青春期生长的时间和强度的决定因素作为风险决定暴露因素发挥了作用。
