Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Int J Epidemiol. 2012 Aug;41(4):1075-85. doi: 10.1093/ije/dys114.
Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub-types, and investigated effect modification by genetic susceptibility to the disease.
We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants.
Among men, we found a positive association between height and glioma risk (≥ 190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (≥ 175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk.
An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease.
一些但不是全部的观察性研究表明，身高较高与患神经胶质瘤的风险显著增加有关。在对观察性研究的汇总分析中，我们研究了这种关联的强度和一致性，总体上以及主要亚型，并研究了疾病遗传易感性对其的影响修饰。
我们对来自 13 项前瞻性研究和 2 项病例对照研究的 1354 例病例和 4734 例对照的个体水平数据进行了标准化和合并。使用基于性别的逻辑回归模型，在校正出生队列和研究后，估计神经胶质瘤和神经胶质瘤亚型的合并比值比（OR）和 95％置信区间（CI）。根据最近确定的 7 种与神经胶质瘤相关的遗传变异，对模型进行分层后，还估计了合并 OR。
在男性中，我们发现身高与神经胶质瘤风险之间存在正相关（≥190 与 170-174cm，合并 OR=1.70，95％CI：1.11-2.61；P 趋势=0.01），在限制为胶质母细胞瘤病例后，这种相关性略有增强（合并 OR=1.99，95％CI：1.17-3.38；P 趋势=0.02）。在女性中，这些关联不太明确（≥175 与 160-164cm，合并 OR 为神经胶质瘤=1.06，95％CI：0.70-1.62；P 趋势=0.22；合并 OR 为胶质母细胞瘤=1.36，95％CI：0.77-2.39；P 趋势=0.04）。总体而言，我们没有发现与神经胶质瘤相关基因型对身高与神经胶质瘤风险之间关联的影响修饰的证据。
成人较高身高与神经胶质瘤的关联，特别是对男性而言更强，对于神经胶质瘤，应进一步研究以阐明身高的环境和遗传决定因素在该疾病病因学中的作用。
