Rosselin Marie, Poeggeler Burkhard, Durand Gregory
Institut des Biomolecules Max Mousseron (IBMM), UMR 5247 CNRS-Universite Montpellier-ENSCM; Universite d'Avignon, Equipe Chimie Bioorganique et Systemes Amphiphiles, 301 rue Baruch de Spinoza BP 21239, 84916 Avignon Cedex 9, France.
Abteilung Stoffwechselphysiologie, Georg-August Universitat Gottingen and Goettingen Research Campus, Am Türmchen 3, 33332 Gutersloh. Germany.
Curr Top Med Chem. 2017;17(18):2006-2022. doi: 10.2174/1568026617666170303115324.
Nitrones have been extensively used for the detection of transient free radicals using electron paramagnetic resonance. Since the mid-80's, nitrones have also been widely used as protective agents against oxidative stress in several biological models. Due to the high potency of nitrones, there has been extensive research on the development of derivatives with improved biological and spin trapping properties as well as enhanced intra-cellular compartmentalization. The chemical and pharmacological properties of nitrones depend mainly on the connectivity as well as on the nature and the position of the substituents on the nitrone group. Therefore, novel bioactive molecules have been designed and the development of specific nitrone derivatives is aimed at providing new therapeutic approaches and perspectives in prevention, treatment and rehabilitation. This review focuses on the effects that are exerted by the most promising nitrone antioxidants that are available. A comprehensive description of the unique molecular mechanism and mediators that are targeted by these compounds is given to guide and enable novel and successful approaches to the treatment of a broad spectrum of diseases associated with stress and aging. New promising nitrone compounds are now available for further development by translational medicine that exert superior bioactivity and efficacy.
硝酮已被广泛用于通过电子顺磁共振检测瞬态自由基。自80年代中期以来，硝酮在多种生物学模型中也被广泛用作抗氧化应激的保护剂。由于硝酮的高效性，人们对开发具有改善的生物学和自旋捕获特性以及增强的细胞内分隔的衍生物进行了广泛研究。硝酮的化学和药理性质主要取决于连接性以及硝酮基团上取代基的性质和位置。因此，人们设计了新型生物活性分子，开发特定的硝酮衍生物旨在为预防、治疗和康复提供新的治疗方法和前景。本综述重点关注现有最有前景的硝酮抗氧化剂所产生的作用。对这些化合物所靶向的独特分子机制和介质进行了全面描述，以指导并实现治疗与应激和衰老相关的广泛疾病的新颖且成功的方法。新的有前景的硝酮化合物现在可通过转化医学进行进一步开发，这些化合物具有卓越的生物活性和功效。
