Pintus Anna, Aragoni M Carla, Cinellu Maria A, Maiore Laura, Isaia Francesco, Lippolis Vito, Orrù Germano, Tuveri Enrica, Zucca Antonio, Arca Massimiliano
Dipartimento di Scienze Chimiche e Geologiche, Università degli Studi di Cagliari, S.S. 554 bivio per Sestu, 09042 Monserrato, Cagliari, Italy.
Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, Via Vienna 2, 07100 Sassari, Italy.
J Inorg Biochem. 2017 May;170:188-194. doi: 10.1016/j.jinorgbio.2017.02.015. Epub 2017 Feb 22.
The novel heteroleptic cyclometalated complex [Au(py-H)(mnt)] (1; py-H=C-deprotonated 2-benzylpyridine; mnt =1,2-dicyanoethene-1,2-dithiolate) was tested against a panel of ten Gram positive (belonging to the Staphylococcus, Streptococcus spp. and Bacillus clausii), Gram negative (E. coli, K. pneumoniae, P. aeruginosa) bacteria and three yeasts belonging to the Candida spp. Complex 1 showed a remarkable bacteriostatic antimicrobial activity against staphylococci, with Minimum Inhibitory Concentration (MIC) values of 1.56 and 3.13μg/mL for S. haemoliticus and S. aureus, respectively. Spectroscopic and electrochemical measurements, supported by Density Functional Theory (DFT) calculations, were exploited to fully investigate the electronic structure of complex 1 and its relationship with the antimicrobial activity.
新型异配位环金属化配合物[Au(py-H)(mnt)]（1；py-H = C-去质子化的2-苄基吡啶；mnt = 1,2-二氰基乙烯-1,2-二硫醇盐）针对一组十种革兰氏阳性菌（属于葡萄球菌属、链球菌属和克劳氏芽孢杆菌）、革兰氏阴性菌（大肠杆菌、肺炎克雷伯菌、铜绿假单胞菌）以及三种念珠菌属酵母进行了测试。配合物1对葡萄球菌显示出显著的抑菌抗菌活性，溶血葡萄球菌和金黄色葡萄球菌的最低抑菌浓度（MIC）值分别为1.56和3.13μg/mL。在密度泛函理论（DFT）计算的支持下，利用光谱和电化学测量全面研究了配合物1的电子结构及其与抗菌活性的关系。
