迈向针对心房颤动射频导管消融过程中病变形成的个体化建模。
Towards patient-specific modelling of lesion formation during radiofrequency catheter ablation for atrial fibrillation.
作者信息
Soor Navjeevan, Morgan Ross, Varela Marta, Aslanidi Oleg V
机构信息
Department of Biomedical Engineering, King's College London, St Thomas' Hospital, London, United Kingdom (
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:489-492. doi: 10.1109/EMBC.2016.7590746.
Radiofrequency catheter ablation procedures are a first-line method of clinical treatment for atrial fibrillation. However, they suffer from suboptimal success rates and are also prone to potentially serious adverse effects. These limitations can be at least partially attributed to the inter- and intra- patient variations in atrial wall thickness, and could be mitigated by patient-specific approaches to the procedure. In this study, a modelling approach to optimising ablation procedures in subject-specific 3D atrial geometries was applied. The approach enabled the evaluation of optimal ablation times to create lesions for a given wall thickness measured from MRI. A nonliner relationship was revealed between the thickness and catheter contact time required for fully transmural lesions. Hence, our approach based on MRI reconstruction of the atrial wall combined with subject-specific modelling of ablation can provide useful information for improving clinical procedures.
射频导管消融术是心房颤动临床治疗的一线方法。然而，其成功率并不理想，且还容易出现潜在的严重不良反应。这些局限性至少部分归因于心房壁厚度在患者之间和患者体内的差异，而针对该手术的个性化方法可以缓解这些问题。在本研究中，应用了一种在特定个体的三维心房几何结构中优化消融手术的建模方法。该方法能够评估根据磁共振成像（MRI）测量的给定壁厚度创建损伤所需的最佳消融时间。结果显示，完全透壁损伤所需的厚度与导管接触时间之间存在非线性关系。因此，我们基于心房壁MRI重建并结合特定个体消融建模的方法可为改进临床手术提供有用信息。
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