• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

用于平坦化和非平坦化射束的 PTW-31016 pinpoint 电离室的现场校正因子。主要不确定度源的研究。

Field correction factors for a PTW-31016 Pinpoint ionization chamber for both flattened and unflattened beams. Study of the main sources of uncertainties.

机构信息

Servei de Física Mèdica i Protecció radiològica, Institut Català d'Oncologia (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.

Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, Edinburgh, Scotland.

出版信息

Med Phys. 2017 May;44(5):1930-1938. doi: 10.1002/mp.12189. Epub 2017 Apr 13.

DOI:10.1002/mp.12189
PMID:28261817
Abstract

PURPOSE

The primary aim of this study was to determine correction factors, kQclin,Qmsrfclin,fmsr for a PTW-31016 ionization chamber on field sizes from 0.5 cm × 0.5 cm to 2 cm × 2 cm for both flattened (FF) and flattened filter-free (FFF) beams produced in a TrueBeam clinical accelerator. The secondary objective was the determination of field output factors, ΩQclin,Qmsrfclin,fmsr over this range of field sizes using both Monte Carlo (MC) simulation and measurements.

METHODS

kQclin,Qmsrfclin,fmsr for the PTW-31016 chamber were calculated by MC simulation for field sizes of 0.5 cm × 0.5 cm, 1 cm × 1 cm, and 2 cm × 2 cm. MC simulations were performed with the PENELOPE code system for the 10 MV FFF Particle Space File from a TrueBeam linear accelerator (LINAC) provided by the manufacturer (Varian Medical Systems, Inc. Palo Alto, CA, USA). Simulations were repeated taking into account chamber manufacturing tolerances and accelerator jaw positioning in order to assess the uncertainty of the calculated correction factors. Output ratios were measured on square fields ranging from 0.5 cm × 0.5 cm to 10 cm × 10 cm for 6 MV and 10 MV FF and FFF beams produced by a TrueBeam using a PTW-31016 ionization chamber; a Sun Nuclear Edge detector (SunNuclear Corp., Melbourne, FL, USA) and TLD-700R (Harshaw, Thermo Scientific, Waltham, MA, USA). The validity of the proposed correction factors was verified using the calculated correction factors for the determination of ΩQclin,Qmsrfclin,fmsr using a PTW-31016 at the four TrueBeam energies and comparing the results with both TLD-700R measurements and MC simulations. Finally, the proposed correction factors were used to assess the correction factors of the SunNuclear Edge detector.

RESULTS

The present work provides a set of MC calculated correction factors for a PTW-31016 chamber used on a TrueBeam FF and FFF mode. For the 0.5 cm × 0.5 cm square field size, kQclin,Qmsrfclin,fmsr is equal to 1.17 with a combined uncertainty of 2% (k = 1). A detailed analysis of the most influential parameters is presented in this work. PTW-31016 corrected measurements were used for the determination of ΩQclin,Qmsrfclin,fmsr for 6 MV and 10 MV FF and FFF and the results were in agreement with values obtained using a TLD-700R detector (differences < 3% for a 0.5 cm square field) for the four energies studied. Uncertainty in field collimation was found to be the main source of influence of ΩQclin,Qmsrfclin,fmsr and caused differences of up to 15% between calculations and measurements for the 0.5 cm × 0.5 cm field. This was also confirmed by repeating the same measurements at two different institutions.

CONCLUSIONS

This study confirms the need to introduce correction factors when using a PTW-31016 chamber and the hypothesis of their low energy dependence. MC simulation has been shown to be a useful methodology to determine detector correction factors for small fields and to analyze the main sources of uncertainty. However, due to the influence of the LINAC jaw setup for field sizes below or equal to 1 cm, MC methods are not recommended in this range for field output factor calculations.

摘要

目的

本研究的主要目的是确定在 TrueBeam 临床加速器中产生的平坦化(FF)和无平坦化滤波器(FFF)射束的从 0.5cm×0.5cm 至 2cm×2cm 的各种射野大小下,PTW-31016 电离室的校正因子 kQclin,Qmsrfclin,fmsr。次要目标是使用蒙特卡罗(MC)模拟和测量来确定在此范围内的射野输出因子 ΩQclin,Qmsrfclin,fmsr。

方法

通过 MC 模拟计算了 0.5cm×0.5cm、1cm×1cm 和 2cm×2cm 射野大小下的 PTW-31016 腔室的 kQclin,Qmsrfclin,fmsr。使用制造商(Varian Medical Systems,Inc.,Palo Alto,CA,USA)提供的 TrueBeam 10MVFFF Particle Space File 用 PENELOPE 代码系统进行了 MC 模拟。为了评估计算校正因子的不确定性,重复了考虑腔室制造公差和加速器机架定位的模拟。使用 TrueBeam 产生的 6MV 和 10MV FF 和 FFF 射束在从 0.5cm×0.5cm 至 10cm×10cm 的方形射野上测量了 PTW-31016 电离室的输出比;SunNuclear Edge 探测器(SunNuclear Corp.,Melbourne,FL,USA)和 TLD-700R(Harshaw,Thermo Scientific,Waltham,MA,USA)。使用在四个 TrueBeam 能量下的 PTW-31016 计算校正因子确定 ΩQclin,Qmsrfclin,fmsr,并将结果与 TLD-700R 测量和 MC 模拟进行比较,验证了所提出的校正因子的有效性。最后,使用提出的校正因子来评估 SunNuclear Edge 探测器的校正因子。

结果

本工作提供了用于 TrueBeam FF 和 FFF 模式的 PTW-31016 腔室的一组 MC 计算校正因子。对于 0.5cm×0.5cm 的方形射野,kQclin,Qmsrfclin,fmsr 等于 1.17,其总不确定度为 2%(k=1)。本工作详细分析了最具影响力的参数。使用 PTW-31016 校正测量值来确定 6MV 和 10MV FF 和 FFF 的 ΩQclin,Qmsrfclin,fmsr,结果与使用 TLD-700R 探测器(对于四个研究的能量,差异<3%对于 0.5cm 方形射野)获得的值一致。研究发现,射野准直的不确定性是影响 ΩQclin,Qmsrfclin,fmsr 的主要因素,对于 0.5cm×0.5cm 射野,计算值与测量值之间的差异可达 15%。在两个不同的机构重复进行相同的测量也证实了这一点。

结论

本研究证实了在使用 PTW-31016 腔室时需要引入校正因子的假设,并验证了其对低能量的依赖性。MC 模拟已被证明是一种有用的方法,可以确定小射野的探测器校正因子,并分析主要的不确定性来源。然而,由于 LINAC 机架设置对小于或等于 1cm 的射野大小的影响,在这个范围内不建议使用 MC 方法进行射野输出因子的计算。

相似文献

1
Field correction factors for a PTW-31016 Pinpoint ionization chamber for both flattened and unflattened beams. Study of the main sources of uncertainties.用于平坦化和非平坦化射束的 PTW-31016 pinpoint 电离室的现场校正因子。主要不确定度源的研究。
Med Phys. 2017 May;44(5):1930-1938. doi: 10.1002/mp.12189. Epub 2017 Apr 13.
2
Properties of IBA Razor Nano Chamber in small-field radiation therapy using 6 MV FF, 6 MV FFF, and 10 MV FFF photon beams.使用 6 MV FF、6 MVFFF 和 10 MVFFF 光子束的 IBA Razor Nano 室在小射野放射治疗中的特性。
Acta Oncol. 2021 Nov;60(11):1419-1424. doi: 10.1080/0284186X.2021.1979644. Epub 2021 Oct 1.
3
Characterization of a 0.8 mmMedscint plastic scintillator detector system for small field dosimetry.用于小野剂量学的 0.8mmMedscint 塑料闪烁探测器系统的特性描述。
Phys Med Biol. 2023 Aug 29;68(17). doi: 10.1088/1361-6560/aceacf.
4
Determination of the KQclinfclin,Qmsr fmsr correction factors for detectors used with an 800 MU/min CyberKnife(®) system equipped with fixed collimators and a study of detector response to small photon beams using a Monte Carlo method.确定配备固定准直器的800 MU/分钟射波刀(®)系统所用探测器的KQclinfclin、Qmsr fmsr校正因子,并使用蒙特卡罗方法研究探测器对小光子束的响应。
Med Phys. 2014 Jul;41(7):071702. doi: 10.1118/1.4881098.
5
A novel method for the determination of field output factors and output correction factors for small static fields for six diodes and a microdiamond detector in megavoltage photon beams.一种用于确定兆伏光子射束中小静态场的六个二极管和微金刚石探测器的野外输出因子和输出校正因子的新方法。
Med Phys. 2019 Feb;46(2):944-963. doi: 10.1002/mp.13318. Epub 2018 Dec 24.
6
Detector density and small field dosimetry: integral versus point dose measurement schemes.探测器密度与小射野剂量学:整体剂量与点剂量测量方案。
Med Phys. 2013 Aug;40(8):082102. doi: 10.1118/1.4812687.
7
Output correction factors for nine small field detectors in 6 MV radiation therapy photon beams: a PENELOPE Monte Carlo study.6兆伏放射治疗光子束中九个小场探测器的输出校正因子:一项PENELOPE蒙特卡罗研究
Med Phys. 2014 Apr;41(4):041711. doi: 10.1118/1.4868695.
8
Output correction factors for small static fields in megavoltage photon beams for seven ionization chambers in two orientations - perpendicular and parallel.用于两种取向(垂直和平行)的七个电离室的兆伏光子束中小静态场的输出修正因子。
Med Phys. 2020 Jan;47(1):242-259. doi: 10.1002/mp.13894. Epub 2019 Nov 25.
9
A geometrical model for the Monte Carlo simulation of the TrueBeam linac.用于TrueBeam直线加速器蒙特卡罗模拟的几何模型。
Phys Med Biol. 2015 Jun 7;60(11):N219-29. doi: 10.1088/0031-9155/60/11/N219. Epub 2015 May 18.
10
[Measurement of peak correction factor of Farmer chamber for calibration of flattening filter free (FFF) clinical photon beams].[用于无均整器(FFF)临床光子束校准的 Farmer 电离室峰值校正因子的测量]
Magy Onkol. 2015 Jun;59(2):119-23. Epub 2015 Mar 26.

引用本文的文献

1
Consistency of small-field dosimetry, on and off axis, in beam-matched linacs used for stereotactic radiosurgery.用于立体定向放射外科的束流匹配直线加速器中小野剂量测定在轴上和离轴的一致性。
J Appl Clin Med Phys. 2021 Feb;22(2):185-193. doi: 10.1002/acm2.13160. Epub 2021 Jan 13.