Othman Mohamed O, Abdelfatah Mohamed M, Padilla Osvaldo, Hussinat Maha, Elhanafi Sherif, Eloliby Mohamed, Torabi Alireza, Hakim Nawar, Boman Darius A
Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, Texas.
Division of Gastroenterology, Department of Internal Medicine, East Carolina University, Greenville, North Carolina.
Diagn Cytopathol. 2017 May;45(5):426-432. doi: 10.1002/dc.23689. Epub 2017 Mar 6.
Endoscopic ultrasound (EUS) fine needle aspiration (FNA) is an integral part in the diagnosis of pancreatic, intestinal and extra-intestinal masses or lesions. There is no clear data on the superiority of the core biopsy needle over standard 22-gauge needles. The aim of this study is to prospectively compare the cellularity yield of three commonly used 22-gauge FNA needles available in the US market.
This is a prospective, randomized study comparing the cellularity yield of three commercially available EUS needles (two standard FNA needles and core biopsy needle). Two blinded pathologists evaluated the cytology specimens based on an already agreed upon cytology score. We included adult patients (18-80 years old) who presented to our endoscopy unit for FNA of pancreatic or extrapancreatic masses.
109 patients (57 F, 52 M) were recruited to the study, 88 lesions were pancreatic lesions. 39 patients were recruited in the EZ Shot 2™ group, 36 in the Procore group and 34 in the Expect™ group. The average cellularity score and the mean number of passes (SD) were not different between the three needles; P = 0.91 and P = 0.16, respectively. There was no difference between the three needles in obtaining an onsite diagnosis (P = 0.627) and no difference in reported adverse events between the three groups.
The cellularity yields, the mean number of passes and reported adverse events were similar in the three compared 22-gauge needles. Diagn. Cytopathol. 2017;45:426-432. © 2017 Wiley Periodicals, Inc.
内镜超声（EUS）细针穿刺抽吸活检（FNA）是诊断胰腺、肠道及肠外肿物或病变的重要组成部分。目前尚无明确数据表明活检针芯相较于标准22号针具有优越性。本研究旨在前瞻性比较美国市场上三种常用的22号FNA针的细胞获取量。
这是一项前瞻性随机研究，比较三种市售EUS针（两种标准FNA针和活检针芯）的细胞获取量。两名盲法病理学家根据已达成共识的细胞学评分对细胞学标本进行评估。纳入因胰腺或胰腺外肿物前来内镜科进行FNA的成年患者（18 - 80岁）。
109例患者（57例女性，52例男性）纳入研究，88处病变为胰腺病变。EZ Shot 2™组纳入39例患者，Procore组纳入36例，Expect™组纳入34例。三种针之间的平均细胞评分和平均穿刺次数（标准差）无差异；P值分别为0.91和0.16。三种针在获得现场诊断方面无差异（P = 0.627），三组报告的不良事件也无差异。
三种比较的22号针在细胞获取量、平均穿刺次数和报告的不良事件方面相似。诊断细胞病理学。2017；45：426 - 432。©2017威利期刊公司。
