可移植性胰岛素瘤对大鼠肠道中血清素浓度的影响。
Effect of a transplantable insulinoma upon serotonin concentrations in the intestine of the rat.
作者信息
Conlon J M, Bailey C J, Flatt P R
机构信息
Clinical Research Group for Gastrointestinal Endocrinology of the Max-Planck-Gesellschaft, University of Göttingen, FRG.
出版信息
Gut. 1987;28 Suppl(Suppl):213-6. doi: 10.1136/gut.28.suppl.213.
Rapid growth of a transplantable insulinoma in rats over a 14 day period results in hyperphagia together with a selective increase in the weight and enteroglucagon (GLI) concentration of the small intestine. Measurement of serotonin concentrations by an HPLC/fluorometric method demonstrated an increase in blood (91%; p less than 0.05) and in extracts of colon (22%; p less than 0.05) but no change in extracts of the small intestine and caecum. The data support the hypothesis that the rise in enteroglucagon is related directly to the growth of the small intestine and is not a non-specific effect of hyperphagia.
大鼠体内可移植性胰岛素瘤在14天内快速生长，导致摄食过量，同时小肠重量和肠高血糖素（GLI）浓度选择性增加。采用高效液相色谱/荧光法测定血清素浓度，结果显示血液中血清素浓度升高（91%；p<0.05），结肠提取物中血清素浓度升高（22%；p<0.05），但小肠和盲肠提取物中血清素浓度无变化。这些数据支持以下假说：肠高血糖素的升高与小肠生长直接相关，而非摄食过量的非特异性效应。
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