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肺管状髓磷脂中膜内颗粒的线性阵列。

Linear arrays of intramembranous particles in pulmonary tubular myelin.

作者信息

Chi E Y, Lagunoff D

出版信息

Proc Natl Acad Sci U S A. 1978 Dec;75(12):6225-9. doi: 10.1073/pnas.75.12.6225.

DOI:10.1073/pnas.75.12.6225
PMID:282638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC393152/
Abstract

Freeze-fracture preparations of tubular myelin in edematous rat lungs reveal the presence of linear arrays of intramembranous particles. The lines of particles are approximately 50 nm apart and appear to correspond to the intersections of sheets of bilayer membranes. Particles are not seen in lamellar bodies but become evident first in membranes transitional between lamellar bodies and tubular myelin. It is proposed that the particles represent a hydrophobic protein that plays a significant role in the organization of tubular myelin.

摘要

对水肿大鼠肺脏中管状髓磷脂进行冷冻断裂制备，结果显示存在膜内颗粒的线性阵列。颗粒线相隔约50纳米，似乎对应于双层膜片的交叉点。在板层小体中未见颗粒，但首先在板层小体与管状髓磷脂之间的过渡膜中变得明显。有人提出，这些颗粒代表一种疏水蛋白，在管状髓磷脂的组织中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/233ec7c9a89c/pnas00022-0492-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/00e683df9488/pnas00022-0490-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/bf23f493893a/pnas00022-0490-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/c8870dbab11b/pnas00022-0490-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/9f8d10403324/pnas00022-0491-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/397ef0fe6620/pnas00022-0492-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/8c81eedb304d/pnas00022-0492-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/233ec7c9a89c/pnas00022-0492-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/00e683df9488/pnas00022-0490-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/bf23f493893a/pnas00022-0490-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/c8870dbab11b/pnas00022-0490-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/9f8d10403324/pnas00022-0491-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/397ef0fe6620/pnas00022-0492-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/8c81eedb304d/pnas00022-0492-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f42d/393152/233ec7c9a89c/pnas00022-0492-c.jpg

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本文引用的文献

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A stereologic electron microscope study of "tubular myelin figures" in alveolar fluids of rat lungs.大鼠肺肺泡液中“管状髓鞘样结构”的体视学电子显微镜研究。
Z Zellforsch Mikrosk Anat. 1966;69:418-27. doi: 10.1007/BF00406293.
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Osmiophilic lamellated bodies and associated material in lung alveolar spaces.肺肺泡腔内的嗜锇性板层小体及相关物质。
Environ Health Perspect. 1984 Apr;55:227-37. doi: 10.1289/ehp.8455227.
4
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Am J Pathol. 1987 Apr;127(1):131-9.
5
Expression of the 35kDa and low molecular weight surfactant-associated proteins in the lungs of infants dying with respiratory distress syndrome.35kDa及低分子量表面活性物质相关蛋白在死于呼吸窘迫综合征婴儿肺部的表达
Am J Pathol. 1989 Jun;134(6):1285-93.
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Quantitation of phosphatidylcholine secretion in lung slices and primary cultures of rat lung cells.大鼠肺切片和原代培养肺细胞中磷脂酰胆碱分泌的定量分析。
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4102-6. doi: 10.1073/pnas.76.8.4102.
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