Sanderson R J, Vatter A E
J Cell Biol. 1977 Sep;74(3):1027-31. doi: 10.1083/jcb.74.3.1027.
A mechanism is suggested by which the membranes of lamellar bodies are converted to tubular myelin (TM) in the lung. It is argued that a simple corrugation of the membranous sheets can produce the TM formation. Such corrugation would occur in response to simple stresses acting on the lamellar body membranes. The intersections of the tubular figures are formed by fusion of adjacent corners in the corrugations. This results in a more stable hydrophobic bonding of phospholipid molecules. Strong supportive evidence for the mechanism is given by electron micrographs of TM formations.
本文提出了一种机制,通过该机制,板层小体的膜在肺中转化为管状髓鞘(TM)。有人认为,膜片的简单波纹化可产生TM的形成。这种波纹化将响应作用于板层小体膜的简单应力而发生。管状结构的交叉点是由波纹中相邻角的融合形成的。这导致磷脂分子形成更稳定的疏水键。TM形成的电子显微镜照片为该机制提供了有力的支持证据。