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肺中板层小体形成管状髓磷脂的一种方式。

A mode of formation of tubular myelin from lamellar bodies in the lung.

作者信息

Sanderson R J, Vatter A E

出版信息

J Cell Biol. 1977 Sep;74(3):1027-31. doi: 10.1083/jcb.74.3.1027.

Abstract

A mechanism is suggested by which the membranes of lamellar bodies are converted to tubular myelin (TM) in the lung. It is argued that a simple corrugation of the membranous sheets can produce the TM formation. Such corrugation would occur in response to simple stresses acting on the lamellar body membranes. The intersections of the tubular figures are formed by fusion of adjacent corners in the corrugations. This results in a more stable hydrophobic bonding of phospholipid molecules. Strong supportive evidence for the mechanism is given by electron micrographs of TM formations.

摘要

本文提出了一种机制,通过该机制,板层小体的膜在肺中转化为管状髓鞘(TM)。有人认为,膜片的简单波纹化可产生TM的形成。这种波纹化将响应作用于板层小体膜的简单应力而发生。管状结构的交叉点是由波纹中相邻角的融合形成的。这导致磷脂分子形成更稳定的疏水键。TM形成的电子显微镜照片为该机制提供了有力的支持证据。

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Alveolar type II cells: studies on the mode of release of lamellar bodies.
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引用本文的文献

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Stability of multilamellar lipid tubules in excess water.多层脂质管在过量水中的稳定性。
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本文引用的文献

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Measurement of forces between lecithin bilayers.卵磷脂双层膜间力的测量。
Nature. 1976 Feb 19;259(5544):601-3. doi: 10.1038/259601a0.

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