来自海洋甲藻尖尾藻的具有抗炎特性的一种新型三氧杂环丁烷和一种磺基喹喔啉基二酰基甘油的表征
Characterization of a New Trioxilin and a Sulfoquinovosyl Diacylglycerol with Anti-Inflammatory Properties from the Dinoflagellate Oxyrrhis marina.
作者信息
Yoon Eun Young, Yang A Reum, Park Jaeyeon, Moon Seung Joo, Jeong Eun Ju, Rho Jung-Rae
机构信息
Environment and Resource Convergence Center, Advanced Institutes of Convergence Technology, Suwon 16229, Korea.
School of Earth and Environmental Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, Korea.
出版信息
Mar Drugs. 2017 Feb 27;15(3):57. doi: 10.3390/md15030057.
Two new compounds-a trioxilin and a sulfoquinovosyl diacylglycerol (SQDG)-were isolated from the methanolic extract of the heterotrophic dinoflagellate cultivated by feeding on dried yeasts. The trioxilin was identified as (4,8,13,16,19) -7(),10(),11()-trihydroxydocosapentaenoic acid (), and the SQDG was identified as (2)-1--hexadecanosy-2--docosahexaenoyl-3--(6-sulfo-α-d-quinovopyranosyl)-glycerol () by a combination of nuclear magnetic resonance (NMR) spectra, mass analyses, and chemical reactions. The two compounds were associated with docosahexaenoic acid, which is a major component of . The two isolated compounds showed significant nitric oxide inhibitory activity on lipopolysaccharide-induced RAW264.7 cells. Compound showed no cytotoxicity against hepatocarcinoma (HepG2), neuroblastoma (Neuro-2a), and colon cancer (HCT-116) cells, while weak cytotoxicity was observed for compound against Neuro-2a cells.
从以干酵母为食培养的异养甲藻的甲醇提取物中分离出两种新化合物——一种三烯甘油酯和一种磺基喹喔啉二酰基甘油（SQDG）。通过核磁共振（NMR）光谱、质谱分析和化学反应相结合的方法，将三烯甘油酯鉴定为（4,8,13,16,19）-7（）,10（）,11（）-三羟基二十二碳五烯酸（），将SQDG鉴定为（2）-1--十六烷酰基-2--二十二碳六烯酰基-3--（6-磺基-α-d-喹诺吡喃糖基）甘油（）。这两种化合物与二十二碳六烯酸有关，二十二碳六烯酸是 的主要成分。这两种分离出的化合物对脂多糖诱导的RAW264.7细胞显示出显著的一氧化氮抑制活性。化合物 对肝癌（HepG2）、神经母细胞瘤（Neuro-2a）和结肠癌细胞（HCT-116）没有细胞毒性，而化合物 对Neuro-2a细胞观察到微弱的细胞毒性。
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