淡水微藻栅藻中单半乳糖基单酰基甘油的一氧化氮抑制活性。
Nitric oxide inhibitory activity of monogalactosylmonoacylglycerols from a freshwater microalgae Chlorella sorokiniana.
机构信息
Institute for Marine Biosciences, National Research Council, 1411 Oxford Street, Halifax, Nova Scotia B3H 3Z1, Canada.
出版信息
Nat Prod Res. 2013;27(11):1028-31. doi: 10.1080/14786419.2012.696255. Epub 2012 Jun 18.
Chemical investigation of the freshwater microalgae Chlorella sorokiniana led to the isolation of a new monogalactosylmonoacylglycerol, namely, (2S)-1-O-(7Z,10Z-hexadecadienoyl)-3-O-β-D-galactopyranosylglycerol (1) together with a known glycolipid (2S)-1-O-(7Z,10Z,13Z-hexadecatrienoyl)-3-O-β-D-galactopyranosylglycerol (2). Both monogalactosylmonoacylglycerols showed dose-dependent nitric oxide (NO) inhibitory activity against lipopolysaccharide-induced NO production in RAW264.7 macrophage cells suggesting their possible use as anti-inflammatory agents.
淡水微藻衣藻的化学成分研究导致了一种新的单半乳糖基单酰基甘油的分离，即（2S）-1-O-（7Z，10Z-十六碳二烯酰基）-3-O-β-D-半乳糖基甘油（1）以及一种已知的糖脂（2S）-1-O-（7Z，10Z，13Z-十六碳三烯酰基）-3-O-β-D-半乳糖基甘油（2）。这两种单半乳糖基单酰基甘油对脂多糖诱导的 RAW264.7 巨噬细胞细胞中一氧化氮（NO）的产生均显示出剂量依赖性的抑制活性，表明它们可能作为抗炎剂使用。
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