Information and Computer Sciences, University of Hawaii at Mānoa, Honolulu, HI 96822.
Konrad Lorenz Institute for Evolution and Cognition Research, Klosterneuburg, Austria A3400.
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2392-E2400. doi: 10.1073/pnas.1619655114. Epub 2017 Mar 6.
Modifier-gene models for the evolution of genetic information transmission between generations of organisms exhibit the reduction principle: Selection favors reduction in the rate of variation production in populations near equilibrium under a balance of constant viability selection and variation production. Whereas this outcome has been proven for a variety of genetic models, it has not been proven in general for multiallelic genetic models of mutation, migration, and recombination modification with arbitrary linkage between the modifier and major genes under viability selection. We show that the reduction principle holds for all of these cases by developing a unifying mathematical framework that characterizes all of these evolutionary models.
选择有利于在恒定生存力选择和变异产生平衡下接近平衡的种群中减少变异产生率。虽然这一结果已经在各种遗传模型中得到证明，但在具有生存力选择的修饰基因和主要基因之间任意连锁的多等位基因突变、迁移和重组修饰的多等位遗传模型中，这一结果尚未得到普遍证明。我们通过开发一个统一的数学框架来证明所有这些情况下的简化原则，该框架可以描述所有这些进化模型。
