Tadida Meli Isabelle Hota, Tankeu Aurel T, Dehayem Mesmin Y, Chelo David, Noubiap Jean Jacques N, Sobngwi Eugene
Isabelle Hota Tadida Meli, Institut Supérieur des Sciences de la Santé, Université des Montagnes, 208 Bangangté, Cameroon.
World J Diabetes. 2017 Feb 15;8(2):74-79. doi: 10.4239/wjd.v8.i2.74.
To investigated the relationship between exercise-induced ambulatory blood pressure measurement (ABPM) abnormalities in type 1 diabetes mellitus (T1DM) adolescents.
We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio (ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1DM patients and 20 matched controls. T1DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure (BP) and renal function according to the general reference population. Non-diabetic controls were adolescents of general population matched for sex, age and BMI.
Mean duration of diabetes was 4.2 ± 2.8 years. The mean 24 h systolic blood pressure (SBP) and diastolic blood pressure (DBP) were respectively 116 ± 9 mmHg in the diabetic group 111 ± 8 mmHg in the non-diabetic ( = 0.06), and 69 ± 7 mm Hg 66 ± 5 mm Hg ( = 0.19). There was no difference in the diurnal pattern of BP in diabetes patients and non-diabetic controls (SBP: 118 ± 10 mmHg 114 ± 10 mmHg, = 0.11; DBP: 71 ± 7 mmHg 68 ± 6 mmHg, = 0.22). Nighttime BP was higher in the diabetic group with respect to SBP (112 ± 11 mmHg 106 ± 7 mmHg, = 0.06) and to the mean arterial pressure (MAP) (89 ± 9 mmHg 81 ± 6 mmHg, = 0.06). ACR at rest was similar in both groups (5.5 mg/g 5.5 mg/g, = 0.74), but significantly higher in diabetes patients after exercise (10.5 mg/g 5.5 mg/g, = 0.03). SBP was higher in patients having exercise-induced albuminuria (116 ± 10 mmHg 108 ± 10 mmHg, = 0.09).
Exercise-induced albuminuria could be useful for early diagnosis of kidney damage in adolescents with T1DM.
研究1型糖尿病（T1DM）青少年运动诱导的动态血压测量（ABPM）异常之间的关系。
我们在喀麦隆雅温得中心医院国家肥胖中心进行了一项病例对照研究。我们比较了20名喀麦隆T1DM患者和20名匹配对照在静息状态和标准化跑步机运动后的24小时ABPM及尿白蛋白与肌酐比值（ACR）。T1DM青少年年龄在12至18岁之间，患糖尿病至少一年，无蛋白尿，根据一般参考人群其诊室血压（BP）和肾功能正常。非糖尿病对照为在性别、年龄和BMI方面匹配的一般人群青少年。
糖尿病平均病程为4.2±2.8年。糖尿病组的平均24小时收缩压（SBP）和舒张压（DBP）分别为116±9 mmHg，非糖尿病组为111±8 mmHg（P = 0.06），以及69±7 mmHg和66±5 mmHg（P = 0.19）。糖尿病患者和非糖尿病对照的血压昼夜模式无差异（SBP：118±10 mmHg对114±10 mmHg，P = 0.11；DBP：71±7 mmHg对68±6 mmHg，P = 0.22）。糖尿病组夜间SBP（112±11 mmHg对106±7 mmHg，P = 0.06）和平均动脉压（MAP）（89±9 mmHg对81±6 mmHg，P = 0.06）较高。静息时两组的ACR相似（5.5 mg/g对5.5 mg/g，P = 0.74），但运动后糖尿病患者的ACR显著更高（10.5 mg/g对5.5 mg/g，P = 0.03）。运动诱导蛋白尿患者的SBP较高（116±10 mmHg对108±10 mmHg，P = 0.09）。
运动诱导的蛋白尿可能有助于T1DM青少年肾脏损伤的早期诊断。
