Tankeu Aurel T, Kaze François Folefack, Noubiap Jean Jacques, Chelo David, Dehayem Mesmin Yefou, Sobngwi Eugene
Aurel T Tankeu, François Folefack Kaze, Mesmin Yefou Dehayem, Eugene Sobngwi, Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, Yaoundé 1364, Cameroon.
World J Nephrol. 2017 Jul 6;6(4):209-216. doi: 10.5527/wjn.v6.i4.209.
To investigate the relationship between circadian variations in blood pressure (BP) and albuminuria at rest, and during exercise in non-hypertensive type 2 diabetes (T2D) patients.
We conducted a cross-sectional study in well controlled T2D patients, non-hypertensive, without clinical proteinuria and normal creatinine clearance. In each participant, we recorded the BP using ambulatory blood pressure monitoring (ABPM) for 24-h, and albuminuria at rest and after a standardized treadmill exercise.
We enrolled 27 type 2 patients with a median age of 52; and a mean duration of diabetes and HbA1c of 3.6 ± 0.8 years and 6.3% ± 0.5% respectively. Using a 24-h ABPM, we recorded a mean diurnal systolic blood pressure (SBP) of 128 ± 17 mmHg nocturnal of 123 ± 19 mmHg ( = 0.004), and mean diurnal diastolic blood pressure (DBP) of 83 ± 11 mmHg nocturnal 78 ± 14 mmHg ( = 0.002). There was a significant difference between albuminuria at rest [median = 23 mg, interquartile range (IQR) = 10-51] and after exercise (median = 35 mg, IQR = 23-80, < 0.001). Patients with exercise induced albuminuria had an increase in nocturnal BP values on all three components (128 mmHg 110 mmHg, = 0.03 for SBP; 83 mmHg 66 mmHg, = 0.04; 106 83, = 0.02 for mean arterial pressure), as well as albuminuric patients at rest. Moreover, exercise induced albuminuria detect a less increase in nocturnal DBP (83 86, = 0.03) than resting albuminuria.
Exercise induced albuminuria is associated with an increase in nocturnal BP values in T2D patients.
研究血压（BP）的昼夜变化与非高血压2型糖尿病（T2D）患者静息及运动时蛋白尿之间的关系。
我们对血糖控制良好、无高血压、无临床蛋白尿且肌酐清除率正常的T2D患者进行了一项横断面研究。在每位参与者中，我们使用动态血压监测（ABPM）记录24小时血压，并记录静息及标准化跑步机运动后的蛋白尿情况。
我们纳入了27例2型患者，中位年龄为52岁；糖尿病平均病程和糖化血红蛋白分别为3.6±0.8年和6.3%±0.5%。使用24小时ABPM，我们记录到日间平均收缩压（SBP）为128±17mmHg，夜间为123±19mmHg（P=0.004），日间平均舒张压（DBP）为83±11mmHg，夜间为78±14mmHg（P=0.002）。静息时蛋白尿[中位数=23mg，四分位间距（IQR）=10-51]与运动后蛋白尿（中位数=35mg，IQR=23-80，P<0.001）之间存在显著差异。运动诱导性蛋白尿患者的夜间血压值在所有三个组成部分均升高（SBP：128mmHg对110mmHg，P=0.03；DBP：83mmHg对66mmHg，P=0.04；平均动脉压：106对83，P=0.02），静息时蛋白尿患者也是如此。此外，运动诱导性蛋白尿患者夜间DBP升高幅度（83对86，P=0.03）小于静息时蛋白尿患者。
运动诱导性蛋白尿与T2D患者夜间血压值升高有关。
