State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou, Fujian 350002, China.
College of Pharmacy, Third Military Medical University , Chongqing 400038, China.
Chem Rev. 2017 Jul 12;117(13):8864-8907. doi: 10.1021/acs.chemrev.6b00516. Epub 2017 Mar 7.
C-H bond activation and decarboxylation are two significant processes in organic synthesis. The combination of these processes provides a novel synthetic strategy, that is, decarboxylative C-H bond functionalization. Considerable attention has been focused on such an active research field. This review offers an overview of the utility of decarboxylative C-H bond functionalization in the synthesis of various organic compounds, such as styrenes, chalcones, biaryls, and heterocycles, covering most of the recent advances of the decarboxylative functionalization of Csp-H, Csp-H, and Csp-H bonds, as well as their scopes, limitations, practical applications, and synthetic potentials.
C-H 键活化和脱羧是有机合成中的两个重要过程。将这两个过程结合起来提供了一种新的合成策略,即脱羧 C-H 键功能化。人们对这一活跃的研究领域给予了相当多的关注。本综述概述了脱羧 C-H 键功能化在合成各种有机化合物(如苯乙烯、查尔酮、联芳烃和杂环化合物)中的应用,涵盖了 Csp-H、Csp-H 和 Csp-H 键脱羧官能化的最新进展及其范围、局限性、实际应用和合成潜力。