Wan Jie-Ping, Gan Lu, Liu Yunyun
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China.
Org Biomol Chem. 2017 Nov 7;15(43):9031-9043. doi: 10.1039/c7ob02011b.
Transition metal-catalyzed C-H bond functionalization has numerous applications in organic synthesis as a powerful type of bond transformation. In particular, the combination of C-H functionalization with other types of chemical transformations in the manner of multicomponent reactions is an even more beneficial tool in the synthesis of small organic molecules because such reactions provide a platform for the rapid generation of high molecular diversity and complexity by making use of the advantages of both latent C-H bond transformation and the multicomponent reaction. Herein, we provide a review highlighting the research advances in the multicomponent reactions built upon transition metal-catalyzed C-H bond functionalization. The content spans from the reactions featuring the functionalization of C(sp)-H, C(sp)-H and C(sp)-H bonds over the last decade.
过渡金属催化的C-H键官能化作为一种强大的键转化类型，在有机合成中有众多应用。特别是，以多组分反应的方式将C-H官能化与其他类型的化学转化相结合，在小分子有机合成中是一种更有益的工具，因为此类反应利用了潜在C-H键转化和多组分反应的优势，为快速生成高分子多样性和复杂性提供了一个平台。在此，我们提供一篇综述，重点介绍基于过渡金属催化的C-H键官能化构建的多组分反应的研究进展。内容涵盖了过去十年中以C(sp)-H、C(sp²)-H和C(sp³)-H键官能化为特征的反应。
