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生殖道组织中人乳头瘤病毒E2蛋白的鉴定。

Identification of the human papillomavirus E2 protein in genital tract tissues.

作者信息

Li C C, Gilden R V, Showalter S D, Shah K V

机构信息

Program Resources, Inc., National Cancer Institute-Frederick Cancer Research Facility, Maryland 21701.

出版信息

J Virol. 1988 Feb;62(2):606-9. doi: 10.1128/JVI.62.2.606-609.1988.

DOI:10.1128/JVI.62.2.606-609.1988
PMID:2826817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC250575/
Abstract

A 27-kilodalton protein representing approximately 60% of the E2 open reading frame of human papillomavirus type 6 (HPV-6) was synthesized in a bacterial expression system. Affinity-purified polyclonal antibody to this protein detected the probable E2 gene product as a 50-kilodalton protein in most condylomas by Western blot (immunoblot) analysis. The E2-positive condylomas were associated with HPV-6, HPV-11, HPV-16, or unidentified HPVs.

摘要

一种代表人类乳头瘤病毒6型（HPV - 6）E2开放阅读框约60%的27千道尔顿蛋白在细菌表达系统中合成。通过蛋白质印迹（免疫印迹）分析，针对该蛋白的亲和纯化多克隆抗体在大多数尖锐湿疣中检测到一种可能的E2基因产物，表现为50千道尔顿的蛋白。E2阳性的尖锐湿疣与HPV - 6、HPV - 11、HPV - 16或未鉴定的HPV相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d74e/250575/965c25816d4b/jvirol00081-0254-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d74e/250575/98185ab65932/jvirol00081-0254-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d74e/250575/965c25816d4b/jvirol00081-0254-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d74e/250575/98185ab65932/jvirol00081-0254-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d74e/250575/965c25816d4b/jvirol00081-0254-b.jpg

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本文引用的文献

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Functions of purified E1A protein microinjected into mammalian cells.显微注射到哺乳动物细胞中的纯化E1A蛋白的功能。
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DNA sequence and genome organization of genital human papillomavirus type 6b.6b型生殖器人乳头瘤病毒的DNA序列与基因组结构
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Biology and biochemistry of papillomaviruses.乳头瘤病毒的生物学与生物化学
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Transcription of episomal papillomavirus DNA in human condylomata acuminata and Buschke-Löwenstein tumours.人尖锐湿疣和Buschke-Löwenstein肿瘤中游离型乳头瘤病毒DNA的转录
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Antibodies to a synthetic oligopeptide that react with herpes simplex virus type 1 and 2 glycoprotein C.与单纯疱疹病毒1型和2型糖蛋白C发生反应的针对合成寡肽的抗体。
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Identification of the human papillomavirus type 6b L1 open reading frame protein in condylomas and corresponding antibodies in human sera.
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