Urivetzky M, Anna P S, Smith A D
Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York.
J Urol. 1988 Jan;139(1):12-4. doi: 10.1016/s0022-5347(17)42273-7.
Plasma osteocalcin levels were measured by radioimmunoassay in 70 consecutive patients with recurrent calcium (sterile) nephrolithiasis during diagnostic evaluation for the cause of the disease. Nephrogenous cyclic adenosine 3,5'-monophosphate levels also were measured in most of the subjects. Included in the sampling, as determined by standard diagnostic criteria, were 12 patients with absorptive hypercalciuria type I, 15 with absorptive hypercalciuria type II, 22 with renal leak hypercalciuria, 11 with normocalciuria, 6 with primary hyperparathyroidism, 3 with renal tubular acidosis and 1 with Paget's disease, as well as 12 control subjects. The observed plasma osteocalcin levels (ng. per ml. mean +/- standard error) were absorptive hypercalciuria I 2.6 +/- 0.20, absorptive hypercalciuria II 3.1 +/- 0.21, renal hypercalciuria 8.7 +/- 0.45, normocalciuric nephrolithiasis 3.3 +/- 0.25, primary hyperparathyroidism 13.2 +/- 0.91, renal tubular acidosis (range) 5.2 to 10.6, Paget's disease 18.0 and control 3.1 +/- 0.20. There were significant differences between the plasma osteocalcin levels of renal hypercalciuria versus primary hyperparathyroidism and renal hypercalciuria/primary hyperparathyroidism versus any other group. There was good correlation between plasma osteocalcin and cyclic adenosine 3,5'-monophosphate data (correlation coefficient 0.72, p less than 0.005). Plasma osteocalcin levels are a potential differential diagnostic tool for patients with stone disease. The diagnostic value compares favorably with that of cyclic adenosine 3,5'-monophosphate, with the advantage that the determination of plasma osteocalcin requires only a single test.
在对70例连续性复发性钙（无菌性）肾结石患者进行疾病病因诊断评估期间，采用放射免疫分析法测定了血浆骨钙素水平。大多数受试者还测定了肾源性环磷酸腺苷水平。根据标准诊断标准，纳入样本的有12例Ⅰ型吸收性高钙尿症患者、15例Ⅱ型吸收性高钙尿症患者、22例肾性高钙尿症患者、11例正常钙尿症患者、6例原发性甲状旁腺功能亢进患者、3例肾小管酸中毒患者和1例佩吉特病患者，以及12名对照受试者。观察到的血浆骨钙素水平（每毫升纳克数，均值±标准误）分别为：Ⅰ型吸收性高钙尿症2.6±0.20、Ⅱ型吸收性高钙尿症3.1±0.21、肾性高钙尿症8.7±0.45、正常钙尿性肾结石3.3±0.25、原发性甲状旁腺功能亢进13.2±0.91、肾小管酸中毒（范围）5.2至10.6、佩吉特病18.0以及对照3.1±0.20。肾性高钙尿症与原发性甲状旁腺功能亢进患者的血浆骨钙素水平之间，以及肾性高钙尿症/原发性甲状旁腺功能亢进患者与其他任何组之间存在显著差异。血浆骨钙素与环磷酸腺苷数据之间存在良好的相关性（相关系数0.72，p<0.005）。血浆骨钙素水平是结石病患者潜在的鉴别诊断工具。其诊断价值与环磷酸腺苷相当，优点是测定血浆骨钙素仅需单次检测。
