Pak C Y
J Urol. 1982 May;127(5):855-8. doi: 10.1016/s0022-5347(17)54106-3.
Diagnostic evaluation was conducted on 34 patients with a single episode of renal stone formation. Absorptive hypercalciuria as disclosed in 55.9 per cent (23.5 percent type I and 32.4 per cent type II), renal hypercalciuria in 11.8 per cent, primary hyperparathyroidism in 2.9 per cent, hyperuricosuric calcium oxalate nephrolithiasis in 8.8 per cent and no metabolic abnormality in 20.6 per cent. Compared to the group with recurrent stone formation the group with a single stone episode had just as severe biochemical abnormalities or laboratory results, such as hypercalciuria and exaggerated calciuric response to oral calcium load in absorptive hypercalciuria, high fasting urinary calcium and cyclic adenosine monophosphate in renal hypercalciuria, hyperuricosuria in hyperuricosuria calcium oxalate nephrolithiasis and low urine volume in no metabolic abnormality. The results suggest that the same physiological and environmental disturbances characterize stone formation in patients with a single stone episode as in those with recurrent stone formation and indicate the need for diagnostic evaluation.
对34例单发肾结石形成患者进行了诊断评估。结果显示，吸收性高钙尿症占55.9%（其中I型占23.5%，II型占32.4%），肾性高钙尿症占11.8%，原发性甲状旁腺功能亢进占2.9%，高尿酸尿性草酸钙肾结石占8.8%，20.6%未发现代谢异常。与复发性结石形成组相比，单发结石组的生化异常或实验室检查结果同样严重，如吸收性高钙尿症中的高钙尿症以及口服钙负荷后钙尿反应过度、肾性高钙尿症中的空腹尿钙和环磷酸腺苷升高、高尿酸尿性草酸钙肾结石中的高尿酸尿症以及无代谢异常组中的低尿量。结果表明，单发结石患者与复发性结石患者的结石形成具有相同的生理和环境干扰因素，提示需要进行诊断评估。
