Wang Chunfang, Chen Yuanyuan, Zhang Ying, Chen Jin, Ding Xiaojing, Ming Dong, Du Jingang
Rehabilitation Medical Department, Tianjin Union Medical Centre, Rehabilitation Medical Research Center of Tianjin, Tianjin 300121, China.
Lab of Neural Engineering & Rehabilitation, Department of Biomedical Engineering, Tianjin University, Tianjin, China.
J Affect Disord. 2017 Jun;215:172-178. doi: 10.1016/j.jad.2017.02.030. Epub 2017 Feb 28.
This study aimed to examine the aberrant EEG oscillation in major depressive subjects with basal ganglia stroke with lesions in different hemispheres.
Resting EEG of 16 electrodes in 58 stroke subjects, 26 of whom had poststroke depression (13 with left-hemisphere lesion and 13 with right) and 32 of whom did not (18 with left lesion and 14 with right), was recorded to obtain spectral power analysis for several frequency bands. Multiple analysis of variance and receiver operating characteristic (ROC) curves were used to identify differences between poststroke depression (PSD) and poststroke non-depression (PSND), treating the different lesion hemispheres separately. Moreover, Pearson linear correlation analysis was conducted to test the severity of depressive symptoms and EEG indices.
PSD with left-hemisphere lesion showed increased beta2 power in frontal and central areas, but PSD with right-hemisphere lesion showed increased theta and alpha power mainly in occipital and temporal regions. Additionally, for left-hemisphere lesions, beta2 power in central and right parietal regions provided high discrimination between PSD and PSND, and for right-hemisphere lesions, theta power was similarly discriminative in most regions, especially temporal regions. We also explored the association between symptoms of depression and the power of abnormal bands, but we found no such relationship.
The sample size was relatively small and included subjects with different lesions of the basal ganglia.
The aberrant EEG oscillation in subjects with PSD differs between subjects with lesions of the left and right hemispheres, suggesting a complex association between depression and lesion location in stroke patients.
本研究旨在探讨基底节区卒中且病变位于不同半球的重度抑郁患者的异常脑电振荡情况。
记录58例卒中患者16个电极的静息脑电，其中26例有卒中后抑郁（13例左侧半球病变，13例右侧半球病变），32例无卒中后抑郁（18例左侧病变，14例右侧病变），以获得多个频段的频谱功率分析结果。采用多因素方差分析和受试者工作特征（ROC）曲线来识别卒中后抑郁（PSD）和卒中后无抑郁（PSND）之间的差异，并分别处理不同病变半球的情况。此外，进行Pearson线性相关分析以检验抑郁症状严重程度与脑电指标之间的关系。
左侧半球病变的PSD患者额叶和中央区β2功率增加，但右侧半球病变的PSD患者θ和α功率增加主要在枕叶和颞叶区域。此外，对于左侧半球病变，中央区和右侧顶叶区域的β2功率在PSD和PSND之间具有较高的区分度，对于右侧半球病变，θ功率在大多数区域，尤其是颞叶区域，同样具有区分度。我们还探讨了抑郁症状与异常频段功率之间的关联，但未发现此类关系。
样本量相对较小，且包括基底节区不同病变的患者。
PSD患者的异常脑电振荡在左侧和右侧半球病变患者中有所不同，提示卒中患者抑郁与病变位置之间存在复杂的关联。
