T 细胞急性淋巴细胞白血病与胸腺细胞：非编码 RNA 的信息

Wallaert Annelynn, Durinck Kaat, Taghon Tom, Van Vlierberghe Pieter, Speleman Frank

Center for Medical Genetics, Ghent University, Ghent, Belgium.

Cancer Research Institute Ghent, Ghent, Belgium.

J Hematol Oncol. 2017 Mar 7;10(1):66. doi: 10.1186/s13045-017-0432-0.

In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs. This was also the case for T cell acute lymphoblastic leukemia, which is a malignant blood disorder arising from oncogenic events during normal T cell development in the thymus. By studying the transcriptomic profile of protein-coding genes, several oncogenic events leading to T cell acute lymphoblastic leukemia (T-ALL) could be identified. In recent years, it became apparent that several of these oncogenes function via microRNAs and long noncoding RNAs. In this review, we give a detailed overview of the studies that describe the noncoding RNAome in T-ALL oncogenesis and normal T cell development.

在过去十年中，非编码RNA在疾病中的作用已明确确立，始于微小RNA，随后扩展到长链非编码RNA。T细胞急性淋巴细胞白血病也是如此，它是一种恶性血液疾病，由胸腺中正常T细胞发育过程中的致癌事件引起。通过研究蛋白质编码基因的转录组图谱，可以识别出导致T细胞急性淋巴细胞白血病（T-ALL）的几种致癌事件。近年来，很明显这些致癌基因中有几种是通过微小RNA和长链非编码RNA发挥作用的。在这篇综述中，我们详细概述了描述T-ALL肿瘤发生和正常T细胞发育中非编码RNA组的研究。