Zhang Xu, Hu Wenqian
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA.
F1000Res. 2016 Jul 20;5. doi: 10.12688/f1000research.8349.1. eCollection 2016.
Mammalian development is under tight control to ensure precise gene expression. Recent studies reveal a new layer of regulation of gene expression mediated by long noncoding RNAs. These transcripts are longer than 200nt that do not have functional protein coding capacity. Interestingly, many of these long noncoding RNAs are expressed with high specificity in different types of cells, tissues, and developmental stages in mammals, suggesting that they may have functional roles in diverse biological processes. Here, we summarize recent findings of long noncoding RNAs in hematopoiesis, which is one of the best-characterized mammalian cell differentiation processes. Then we provide our own perspectives on future studies of long noncoding RNAs in this field.
哺乳动物的发育受到严格调控，以确保精确的基因表达。最近的研究揭示了由长链非编码RNA介导的基因表达调控的新层面。这些转录本长度超过200个核苷酸，没有功能性蛋白质编码能力。有趣的是，许多此类长链非编码RNA在哺乳动物的不同类型细胞、组织和发育阶段中具有高度特异性表达，这表明它们可能在多种生物学过程中发挥功能性作用。在此，我们总结了长链非编码RNA在造血作用方面的最新研究发现，造血作用是哺乳动物细胞分化过程中特征最明显的过程之一。然后，我们就该领域长链非编码RNA的未来研究提供了自己的观点。
