Wei Shuyong, Wang Kankan
State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025 China.
State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Rd, Shanghai, 200025 China ; Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China.
Exp Hematol Oncol. 2016 Dec 12;5:30. doi: 10.1186/s40164-016-0059-9. eCollection 2015.
Long noncoding RNAs (lncRNAs) have emerged as a class of pivotal regulators of gene expression. Recent studies have shown that lncRNAs contribute to the initiation, maintenance, and development of acute myeloid leukemia (AML). In this review, we summarize the current knowledge of the lncRNAs that play critical roles in AML. We first briefly describe the characteristics of lncRNAs, and then focus on their regulatory roles in AML, including the modulation of differentiation, proliferation, cell cycle, and apoptosis. We further emphasize the action of lncRNAs during leukemogenesis by describing how they interact with RNA, protein and chromatin DNA to exert their functions. We also highlight an urgent need to investigate the mechanisms by which lncRNAs contribute to the pathogenesis of AML. Finally, we discuss the prognostic value of lncRNAs in AML patients.
长链非编码RNA（lncRNAs）已成为一类关键的基因表达调节因子。最近的研究表明，lncRNAs在急性髓系白血病（AML）的起始、维持和发展中发挥作用。在本综述中，我们总结了目前对在AML中起关键作用的lncRNAs的认识。我们首先简要描述lncRNAs的特征，然后重点阐述它们在AML中的调节作用，包括对分化、增殖、细胞周期和凋亡的调控。我们通过描述lncRNAs如何与RNA、蛋白质和染色质DNA相互作用以发挥其功能，进一步强调其在白血病发生过程中的作用。我们还强调迫切需要研究lncRNAs促成AML发病机制的机制。最后，我们讨论lncRNAs在AML患者中的预后价值。
