Farello G, Ferrara P, Antenucci A, Basti C, Verrotti A
Department of Pediatrics, University of L'Aquila, Via Vetoio 1, Coppito, 67100, L'Aquila, Italy.
Department of Pediatrics, Catholic University, A. Gemelli Hospital, Rome, Italy.
Ital J Pediatr. 2017 Mar 7;43(1):27. doi: 10.1186/s13052-017-0344-1.
Obesity and headache are two highly prevalent diseases both in adults and children and they are associated with a strong personal and social impact. Many studies suggest that obesity is comorbid with headache in general, and migraine in particular and obesity seems to be a risk factor for migraine progression and for migraine frequency both in adults and in children. Research shows that there are multiple areas of overlap between migraine pathophysiology and the central and peripheral pathways regulating feeding: inflammatory mediators such as the calcitonin gene-related protein (CGRP), neurotransmitters such as serotonin, peptides such as orexin and adipocytokines such as adiponectin (ADP) and leptin could explain the common pathogenesis. In this paper we discussed the association between obesity and migraine through the analysis of the most recent studies in children and we reviewed data from literature in order to assess the association between obesity and headache and to clarify the possible common pathogenic mechanisms.
肥胖和头痛是成人和儿童中两种高度常见的疾病，它们会对个人和社会产生重大影响。许多研究表明，肥胖通常与头痛共病，尤其是偏头痛，而且肥胖似乎是成人和儿童偏头痛进展和发作频率的一个危险因素。研究表明，偏头痛病理生理学与调节进食的中枢和外周途径之间存在多个重叠领域：诸如降钙素基因相关肽（CGRP）等炎症介质、诸如血清素等神经递质、诸如食欲素等肽类以及诸如脂联素（ADP）和瘦素等脂肪细胞因子可能解释了共同的发病机制。在本文中，我们通过分析儿童最新研究来探讨肥胖与偏头痛之间的关联，并回顾文献数据以评估肥胖与头痛之间的关联，并阐明可能的共同致病机制。
