运动的自噬依赖性有益作用。
Autophagy-Dependent Beneficial Effects of Exercise.
作者信息
Halling Jens Frey, Pilegaard Henriette
机构信息
Department of Biology, University of Copenhagen, 2100 Copenhagen, Denmark.
出版信息
Cold Spring Harb Perspect Med. 2017 Aug 1;7(8):a029777. doi: 10.1101/cshperspect.a029777.
Abstract
Exercise has long been recognized as a powerful physiological stimulus for a wide variety of metabolic adaptations with implications for health and performance. The metabolic effects of exercise occur during and after each exercise bout and manifest as cumulative adaptive responses to successive exercise bouts. Studies on the beneficial effects of exercise have traditionally focused on the biosynthesis of metabolic proteins and organelles. However, the recycling of cellular components by autophagy has recently emerged as an important process involved in the adaptive responses to exercise. This review covers the regulation of autophagy by exercise, with emphasis on the potential autophagy-dependent beneficial effects of exercise.
摘要
长期以来，运动一直被认为是一种强大的生理刺激，可引发多种代谢适应，对健康和体能表现具有重要意义。运动的代谢效应在每次运动期间及之后都会发生，并表现为对连续运动回合的累积适应性反应。传统上，关于运动有益效果的研究主要集中在代谢蛋白质和细胞器的生物合成上。然而，自噬介导的细胞成分循环利用最近已成为参与运动适应性反应的一个重要过程。本综述涵盖了运动对自噬的调节作用，重点关注运动潜在的依赖自噬的有益效果。
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