Aiyelabola Temitayo, Akinkunmi Ezekiel, Obuotor Efere, Olawuni Idowu, Isabirye David, Jordaan Johan
Department of Chemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
Bioinorg Chem Appl. 2017;2017:6426747. doi: 10.1155/2017/6426747. Epub 2017 Feb 7.
Coordination compounds of 4-hydroxy-3-nitro-2-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand complexes, in basic media. The compounds formed were characterized using infrared, Uv-vis spectrophotometric analyses, mass spectrometry, magnetic susceptibility measurements, and EDX analyses. It was concluded that 4-hydroxy-3-nitro-2-chromen-2-one coordinated as a monobasic ligand for all the complexes; it also coordinated via the carbonyl moiety in the case of the Cu(II) mixed ligand complexes. Similarly it was proposed that the amino acids also coordinated in a bidentate fashion via their amino nitrogen and carboxylate oxygen atoms. The synthesized compounds were screened for their antimicrobial and cytotoxic activities. The complexes exhibited marginal antimicrobial activity but good cytotoxic activity.
通过在碱性介质中使铜（II）盐和锌（II）盐反应，合成了4-羟基-3-硝基-2-色烯-2-酮的配位化合物及其与氨基乙酸和脯氨酸-2-羧酸的混合配体配合物，其中香豆素配合物的摩尔比为1∶2，混合配体配合物的摩尔比为1∶1∶1。使用红外光谱、紫外可见分光光度分析、质谱、磁化率测量和能谱分析对所形成的化合物进行了表征。得出的结论是，对于所有配合物，4-羟基-3-硝基-2-色烯-2-酮作为一元配体进行配位；在铜（II）混合配体配合物的情况下，它还通过羰基部分进行配位。同样，有人提出氨基酸也通过其氨基氮和羧酸盐氧原子以双齿方式进行配位。对合成的化合物进行了抗菌和细胞毒性活性筛选。这些配合物表现出微弱的抗菌活性，但具有良好的细胞毒性活性。
