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本文引用的文献

1
Patients Scheduled for Chondrocyte Implantation Treatment with MACI Have Larger Defects than Those Enrolled in Clinical Trials.计划接受MACI软骨细胞植入治疗的患者比参加临床试验的患者有更大的缺损。
Cartilage. 2016 Apr;7(2):140-8. doi: 10.1177/1947603515622659. Epub 2015 Dec 23.
2
Injectable biomaterials: a perspective on the next wave of injectable therapeutics.可注射生物材料:对下一波可注射治疗药物的展望。
Biomed Mater. 2016 Feb 2;11(1):014110. doi: 10.1088/1748-6041/11/1/014110.
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Predictors for 1-year mortality following hip fracture: a retrospective review of 465 consecutive patients.髋部骨折后1年死亡率的预测因素:对465例连续患者的回顾性研究
Eur J Trauma Emerg Surg. 2017 Feb;43(1):113-119. doi: 10.1007/s00068-015-0556-2. Epub 2015 Aug 11.
4
Autologous Dual-Tissue Transplantation for Osteochondral Repair: Early Clinical and Radiological Results.用于骨软骨修复的自体双组织移植:早期临床和放射学结果
Cartilage. 2015 Jul;6(3):166-73. doi: 10.1177/1947603515580983.
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Knee Cartilage Defect Patients Enrolled in Randomized Controlled Trials Are Not Representative of Patients in Orthopedic Practice.随机对照试验纳入的膝关节软骨缺损患者不能代表骨科实践中的患者。
Cartilage. 2010 Oct;1(4):312-9. doi: 10.1177/1947603510373917.
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Cell microenvironment engineering and monitoring for tissue engineering and regenerative medicine: the recent advances.用于组织工程和再生医学的细胞微环境工程与监测:最新进展
Biomed Res Int. 2014;2014:921905. doi: 10.1155/2014/921905. Epub 2014 Jul 20.
7
Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration.基于间充质干细胞的软骨修复和再生策略的进展。
Stem Cell Rev Rep. 2014 Oct;10(5):686-96. doi: 10.1007/s12015-014-9526-z.
8
Towards Deeper Research and Better Policy for Healthy Aging --Using the Unique Data of Chinese Longitudinal Healthy Longevity Survey.迈向更深入的健康老龄化研究与更完善的政策——利用中国老年健康影响因素跟踪调查的独特数据
China Economic J. 2012;5(2-3):131-149. doi: 10.1080/17538963.2013.764677.
9
Injectable cultured bone marrow-derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years' follow-up.注射用培养骨髓间充质干细胞治疗伴有软骨缺损的内翻膝骨关节炎行胫骨高位截骨术后:一项前瞻性、随机对照临床试验,随访 2 年。
Arthroscopy. 2013 Dec;29(12):2020-8. doi: 10.1016/j.arthro.2013.09.074.
10
Autologous stem cell therapy maintains vertebral blood flow and contrast diffusion through the endplate in experimental intervertebral disc degeneration.自体干细胞治疗通过终板维持实验性椎间盘退变中的椎骨血流和对比扩散。
Spine (Phila Pa 1976). 2011 Mar 15;36(6):E373-9. doi: 10.1097/BRS.0b013e3181dce34c.

奥胡斯再生骨科研讨会(AROS)。

Aarhus Regenerative Orthopaedics Symposium (AROS).

作者信息

Foldager Casper B, Bendtsen Michael, Berg Lise C, Brinchmann Jan E, Brittberg Mats, Bunger Cody, Canseco Jose, Chen Li, Christensen Bjørn B, Colombier Pauline, Deleuran Bent W, Edwards James, Elmengaard Brian, Farr Jack, Gatenholm Birgitta, Gomoll Andreas H, Hui James H, Jakobsen Rune B, Joergensen Natasja L, Kassem Moustapha, Koch Thomas, Kold Søren, Krogsgaard Michael R, Lauridsen Henrik, Le Dang, Le Visage Catherine, Lind Martin, Nygaard Jens V, Olesen Morten L, Pedersen Michael, Rathcke Martin, Richardson James B, Roberts Sally, Rölfing Jan H D, Sakai Daisuke, Toh Wei Seong, Urban Jill, Spector Myron

机构信息

a Orthopaedic Research Laboratory , Aarhus University Hospital , Denmark.

b Department of Orthopaedics , Aarhus University Hospital , Denmark.

出版信息

Acta Orthop. 2016 Dec;87(sup363):1-5. doi: 10.1080/17453674.2017.1297918. Epub 2017 Mar 8.

DOI:10.1080/17453674.2017.1297918
PMID:28271925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5389427/
Abstract

The combination of modern interventional and preventive medicine has led to an epidemic of ageing. While this phenomenon is a positive consequence of an improved lifestyle and achievements in a society, the longer life expectancy is often accompanied by decline in quality of life due to musculoskeletal pain and disability. The Aarhus Regenerative Orthopaedics Symposium (AROS) 2015 was motivated by the need to address regenerative challenges in an ageing population by engaging clinicians, basic scientists, and engineers. In this position paper, we review our contemporary understanding of societal, patient-related, and basic science-related challenges in order to provide a reasoned roadmap for the future to deal with this compelling and urgent healthcare problem.

摘要

现代介入医学与预防医学的结合导致了老龄化的流行。虽然这种现象是生活方式改善和社会成就的积极结果,但预期寿命的延长往往伴随着因肌肉骨骼疼痛和残疾导致的生活质量下降。2015年奥胡斯再生骨科研讨会(AROS)的召开是出于通过让临床医生、基础科学家和工程师参与来应对老龄化人口中的再生挑战的需要。在本立场文件中,我们回顾了我们对社会、患者相关和基础科学相关挑战的当代理解,以便为未来提供一个合理的路线图,以应对这一紧迫且迫切的医疗保健问题。