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肌肉骨骼系统的衰老

Ageing in the musculoskeletal system.

作者信息

Roberts Sally, Colombier Pauline, Sowman Aneka, Mennan Claire, Rölfing Jan H D, Guicheux Jérôme, Edwards James R

机构信息

a Spinal Studies and ISTM , Keele University, and Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust , Oswestry , UK.

b INSERM U791-LIOAD , Centre Hospitalo-Universitaire (CHU) de Nantes , Nantes , France.

出版信息

Acta Orthop. 2016 Dec;87(sup363):15-25. doi: 10.1080/17453674.2016.1244750. Epub 2016 Oct 17.

DOI:10.1080/17453674.2016.1244750
PMID:27748151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5389428/
Abstract

The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment.

摘要

在生命历程中，肌肉骨骼系统的老化程度会影响生活质量和寿命。骨质流失、关节软骨退化以及椎间盘退变、变窄是骨骼老化的主要特征，它们共同导致疼痛和行动能力丧失。本综述涵盖了构成肌肉骨骼系统一些关键组成部分的细胞成分，并总结了2015年奥尔胡斯再生骨科研讨会（AROS）（老年人群中的再生）关于每种特定细胞类型在老化骨骼微环境中如何变化的讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/58a874c105c1/iort-87-15.F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/660189d8a8a9/iort-87-15.F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/eee8a7dd66d7/iort-87-15.F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/0bed1c9bd721/iort-87-15.F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/58a874c105c1/iort-87-15.F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/660189d8a8a9/iort-87-15.F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/eee8a7dd66d7/iort-87-15.F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/0bed1c9bd721/iort-87-15.F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/081b/5389428/58a874c105c1/iort-87-15.F04.jpg

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