Wei Lingli, Ke Zunyu, Zhao Yu, Cai Zhiyou
aDepartment of Neurology, Xiangyang Central Hospital, the Affiliated Hospital of Hubei University of Arts and Science, Xiangyang bDepartment of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province cDepartment of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province dDepartment of Neurology, Chongqing General Hospital, Chongqing, Chongqing municipality, People's Republic of China.
Neuroreport. 2017 Apr 12;28(6):325-330. doi: 10.1097/WNR.0000000000000765.
There is a strong association between lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and atherosclerosis-related diseases. The aim of this study was to investigate the role of Lp-PLA2 in the ischemic stroke and further offer clinical evidence that measuring Lp-PLA2 helps predict the risk of stroke occurrence and recurrence. A total of 328 hospitalized patients were recruited, including 179 cases of acute cerebral infarction (ACI) and 149 non-ACI controls. The serum level of Lp-PLA2 in ACI was significantly higher than non-ACI. The serum level of Lp-PLA2 in the recurrence of ACI was significantly higher than the nonrecurrence. The serum levels of Lp-PLA2 in large-artery atherosclerosis subtype were the highest among the subtypes of the Trial of Org 10172 in Acute Stroke Treatment and non-ACI controls. The level of Lp-PLA2 in large-artery atherosclerosis and the cardioembolism group was statistically significantly higher than that of the control cases. There was no statistically significant difference between the small-vessel occlusion group and the control cases. The present study confirmed that the elevated Lp-PLA2 level can be a risk factor for ischemic stroke in the Chinese population. The serum level of Lp-PLA2 may be a predictive factor for the recurrence of ACI.
脂蛋白相关磷脂酶A2（Lp-PLA2）水平与动脉粥样硬化相关疾病之间存在密切关联。本研究旨在探讨Lp-PLA2在缺血性卒中中的作用，并进一步提供临床证据，证明检测Lp-PLA2有助于预测卒中发生和复发的风险。共招募了328例住院患者，包括179例急性脑梗死（ACI）患者和149例非ACI对照者。ACI患者的血清Lp-PLA2水平显著高于非ACI患者。ACI复发患者的血清Lp-PLA2水平显著高于未复发患者。在急性卒中治疗Org 10172试验的亚型和非ACI对照者中，大动脉粥样硬化亚型的血清Lp-PLA2水平最高。大动脉粥样硬化和心源性栓塞组的Lp-PLA2水平在统计学上显著高于对照组。小血管闭塞组与对照组之间无统计学显著差异。本研究证实，Lp-PLA2水平升高可能是中国人群缺血性卒中的一个危险因素。血清Lp-PLA2水平可能是ACI复发的一个预测因素。
