Shen Liping, Yang Jiangsheng, Zhu Zufu, Li Weizhang, Cui Junyou, Gu Lingyun
Department of Neurology, Jiangyin Hospital Affiliated to Nantong University, Jiangyin, Jiangsu, People's Republic of China.
J Inflamm Res. 2024 Sep 30;17:6887-6894. doi: 10.2147/JIR.S477415. eCollection 2024.
The study aimed to investigate the correlation between baseline serum levels of high mobility group box 1 (HMGB1) and the recurrence of acute ischemic stroke (AIS).
A total of 544 AIS patients were enrolled and followed up monthly. Serum HMGB1 levels were measured using enzyme-linked immunosorbent assay (ELISA). The primary endpoint was the first recurrence of AIS.
During a median follow-up period of 43 months, 62 of the 544 AIS patients experienced a recurrence. Both HMGB1 levels and national institute of health stroke scale (NIHSS) scores were significantly higher in the recurrence group compared to the no-recurrence group (p<0.05). According to the receiver operating characteristic curve analysis, the combination (0.855, 95% CI: 0.800-0.911) of HMGB1 (0.745, 95% CI: 0.663-0.826) and NIHSS (0.822, 95% CI: 0.758-0.886) had a higher value for predicting AIS recurrence than either of them (p<0.05). Kaplan-Meier analyses demonstrated that the cumulative survival without AIS recurrence was significantly lower in patients in the high HMGB1 level group than in the low HMGB1 level group (p<0.05). The multifactorial Cox analyses indicated that elevated baseline serum HMGB1 levels (HR: 7.489, 95% CI:4.383-12.795) were a highly effective predictor of recurrence in AIS.
Elevated baseline serum HMGB1 levels were found to be a highly effective predictor of recurrence in AIS.
本研究旨在探讨基线血清高迁移率族蛋白B1（HMGB1）水平与急性缺血性卒中（AIS）复发之间的相关性。
共纳入544例AIS患者，并每月进行随访。采用酶联免疫吸附测定（ELISA）法检测血清HMGB1水平。主要终点是AIS的首次复发。
在中位随访期43个月期间，544例AIS患者中有62例复发。复发组的HMGB1水平和美国国立卫生研究院卒中量表（NIHSS）评分均显著高于未复发组（p<0.05）。根据受试者工作特征曲线分析，HMGB1（0.745，95%CI：0.663-0.826）和NIHSS（0.822，95%CI：0.758-0.886）的联合指标（0.855，95%CI：0.800-0.911）预测AIS复发的价值高于它们中的任何一个（p<0.05）。Kaplan-Meier分析表明，高HMGB1水平组患者无AIS复发的累积生存率显著低于低HMGB1水平组（p<0.05）。多因素Cox分析表明，基线血清HMGB1水平升高（HR：7.489，95%CI：4.383-12.795）是AIS复发的高效预测指标。
发现基线血清HMGB1水平升高是AIS复发的高效预测指标。
