Méhes Gábor
Patológiai Intézet, Debreceni Egyetem ÁOK, Debrecen, Hungary.
Magy Onkol. 2017 Mar 8;61(1):81-87. Epub 2016 Mar 20.
Lymphoproliferative diseases of the central nervous system are rare, diagnostics and treatment are accordingly challenging. Since the introduction of the 2008 WHO lymphoma classification, primary CNS DLBCL - also covering the associated primary ocular (vitreoretinal) lymphoma - is a separate entity. The special localization is related with a series of newly recognized genetic, genomic and immunologic features directing to the strong interaction between transformed lymphoma cells, neural tissue components and the local immune response. Histological differentiation is frequently disabled by the limited sampling opportunities and requires the application of all available hematopathologic technologies including immunohistochemistry, cytology, liquor serology, flow cytometry, fluorescence in situ hybridization and polymerase chain reaction with sequencing.
中枢神经系统的淋巴增殖性疾病较为罕见，因此诊断和治疗颇具挑战性。自2008年世界卫生组织淋巴瘤分类引入以来，原发性中枢神经系统弥漫性大B细胞淋巴瘤（DLBCL）——也涵盖相关的原发性眼（玻璃体视网膜）淋巴瘤——是一个独立的实体。其特殊的定位与一系列新认识到的遗传、基因组和免疫特征相关，这些特征表明转化的淋巴瘤细胞、神经组织成分和局部免疫反应之间存在强烈的相互作用。由于采样机会有限，组织学分化常常受到影响，这就需要应用所有可用的血液病理学技术，包括免疫组织化学、细胞学、脑脊液血清学、流式细胞术、荧光原位杂交以及测序聚合酶链反应。
