Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Obes Rev. 2017 May;18(5):526-546. doi: 10.1111/obr.12515. Epub 2017 Mar 8.
This study examines the differences in bone mineral density between normal-weight children and children with overweight or obesity.
A systematic review and meta-analysis of observational studies (published up to 22 June 2016) on the differences in bone mineral density between normal-weight children and overweight and obese children was performed. Results were pooled when possible and mean differences (MDs) were calculated between normal-weight and overweight and normal-weight and obese children for bone content and density measures at different body sites.
Twenty-seven studies, with a total of 5,958 children, were included. There was moderate and high quality of evidence that overweight (MD 213 g; 95% confidence interval [CI] 166, 261) and obese children (MD 329 g; 95%CI [229, 430]) have a significantly higher whole body bone mineral content than normal-weight children. Similar results were found for whole body bone mineral density. Sensitivity analysis showed that the association was stronger in girls.
Overweight and obese children have a significantly higher bone mineral density compared with normal-weight children. Because there was only one study included with a longitudinal design, the long-term impact of childhood overweight and obesity on bone health at adulthood is not clear.
本研究旨在探讨正常体重儿童与超重或肥胖儿童之间骨密度的差异。
对截至 2016 年 6 月 22 日发表的关于正常体重儿童与超重和肥胖儿童之间骨密度差异的观察性研究进行了系统回顾和荟萃分析。在可能的情况下对结果进行了汇总，并计算了不同身体部位的骨含量和密度测量值中正常体重与超重、正常体重与肥胖儿童之间的均值差异（MD）。
共纳入 27 项研究，总计 5958 名儿童。有中度和高度质量证据表明，超重（MD 213g；95%置信区间[CI] 166，261）和肥胖儿童（MD 329g；95%CI [229，430]）的全身骨矿物质含量明显高于正常体重儿童。全身骨矿物质密度也有类似的结果。敏感性分析显示，这种关联在女孩中更强。
超重和肥胖儿童的骨密度明显高于正常体重儿童。由于只有一项研究采用了纵向设计，因此尚不清楚儿童期超重和肥胖对成年期骨骼健康的长期影响。
