Sotiriadis Alexandros, Eleftheriades Makarios, Papadopoulos Vassileios, Sarafidis Kosmas, Pervanidou Panagiota, Assimakopoulos Efstratios
a Second Department of Obstetrics and Gynecology , Aristotle University of Thessaloniki , Thessaloniki , Greece.
b Second Department of Obstetrics and Gynecology , National and Kapodistrian University of Athens , Athens , Greece.
J Matern Fetal Neonatal Med. 2018 Mar;31(6):761-769. doi: 10.1080/14767058.2017.1297409. Epub 2017 Mar 8.
To evaluate differences in distribution of estimated fetal weight (EFW) and birth weight (BW) of ongoing fetuses and neonates of the same gestational age.
Reference curves for EFW (Hadlock BPD-HC-AC-FL formula, N = 1191) and BW (N = 1036) in singleton pregnancies from 24 to 40 gestational weeks were calculated. Multiple pregnancies, fetuses with major or multiple abnormalities or syndromes and iatrogenic preterm deliveries due to preeclampsia or abnormal fetal Doppler were excluded. The standardized residuals for EFW and BW were calculated and compared.
EFW and BW can be accurately described by quadratic equations (R = 0.944 and 0.807, respectively). The distribution of standardized residuals for BW using the EFW formula was negative from 28 to 35 weeks. The 50th and 5th centiles of BW were lower than those of EFW throughout prematurity, and they converged at approximately 38 gestational weeks. The 5th centile for BW was 30% lower than the 5th centile for EFW at 27 weeks, 27.5% lower at 30 weeks and 19.4% at 34 weeks.
Preterm infants have lower BW distribution compared to the expected EFW of ongoing pregnancies of the same gestational age, supporting the concept of hidden intrauterine morbidity for a proportion of these infants.
评估同一孕周的存活胎儿与新生儿的估计胎儿体重（EFW）及出生体重（BW）分布的差异。
计算24至40孕周单胎妊娠中EFW（哈德洛克双顶径-头围-腹围-股骨长公式，N = 1191）和BW（N = 1036）的参考曲线。排除多胎妊娠、有严重或多发畸形或综合征的胎儿以及因子痫前期或异常胎儿多普勒检查导致的医源性早产。计算并比较EFW和BW的标准化残差。
EFW和BW可用二次方程准确描述（R分别为0.944和0.807）。使用EFW公式时，28至35周BW标准化残差的分布为负值。在整个早产期间，BW的第50和第5百分位数低于EFW，且在约38孕周时两者趋于一致。27周时BW的第5百分位数比EFW的第5百分位数低30%，30周时低27.5%，34周时低19.4%。
与相同孕周存活妊娠的预期EFW相比，早产儿的BW分布较低，这支持了部分此类婴儿存在隐匿性宫内发病的概念。
