Study Program of Statistics, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat University, Banjarbaru, South Kalimantan, Indonesia.
School of Science, College of Science, Engineering, and Health, RMIT University, Melbourne, Victoria, Australia.
PLoS One. 2020 Oct 13;15(10):e0240436. doi: 10.1371/journal.pone.0240436. eCollection 2020.
A fetal growth chart is a vital tool for assessing fetal risk during pregnancy. Since fetal weight cannot be directly measured, its reliable estimation at different stages of pregnancy has become an essential issue in obstetrics and gynecology and one of the critical elements in developing a fetal growth chart for estimated fetal weight. In Indonesia, however, a reliable model and data for fetal weight estimation remain challenging, and this causes the absence of a standard fetal growth chart in antenatal care practices. This study has reviewed and evaluated the efficacy of the prediction models used to develop the most prominent growth charts for estimated fetal weight. The study also has discussed the potential challenges when such surveillance tools are utilized in low resource settings. The study, then, has proposed an alternative model based only on maternal fundal height to estimate fetal weight. Finally, the study has developed an alternative growth chart and assessed its capability in detecting abnormal patterns of fetal growth during pregnancy. Prospective data from twenty selected primary health centers in South Kalimantan, Indonesia, were used for the proposed model validation, the comparison task, and the alternative growth chart development using both descriptive and inferential statistics. Results show that limited access to individual fetal biometric characteristics and low-quality data on personal maternal and neonatal characteristics make the existing fetal growth charts less applicable in the local setting. The proposed model based only on maternal fundal height has a comparable ability in predicting fetal weight with less error than the existing models. The results have shown that the developed chart based on the proposed model can effectively detect signs of abnormality, between 20 and 41 weeks, among low birth weight babies in the absence of ultrasound. Consequently, the developed chart would improve the quality of fetal risk assessment during pregnancy and reduce the risk of adverse neonatal outcomes.
胎儿生长图表是评估妊娠期间胎儿风险的重要工具。由于无法直接测量胎儿体重,因此在妊娠的不同阶段可靠地估计其体重已成为妇产科的重要问题,也是制定估计胎儿体重的胎儿生长图表的关键因素之一。然而,在印度尼西亚,可靠的胎儿体重估计模型和数据仍然具有挑战性,这导致产前保健实践中缺乏标准的胎儿生长图表。本研究回顾和评估了用于开发最突出的估计胎儿体重生长图表的预测模型的功效。该研究还讨论了在资源有限的环境中使用此类监测工具时可能遇到的挑战。然后,该研究提出了一种仅基于母体宫底高度的替代模型来估计胎儿体重。最后,该研究开发了一种替代生长图表,并评估了其在检测妊娠期间胎儿生长异常模式的能力。来自印度尼西亚南加里曼丹的 20 个选定初级保健中心的前瞻性数据用于验证所提出的模型、比较任务和替代生长图表的开发,使用描述性和推断性统计方法。结果表明,由于无法获得个体胎儿生物特征的有限访问权以及个人母婴特征的低质量数据,现有的胎儿生长图表在当地环境中的适用性降低。仅基于母体宫底高度的提出的模型在预测胎儿体重方面具有相当的能力,且误差小于现有模型。结果表明,基于所提出的模型开发的图表可以在没有超声的情况下,在 20 至 41 周之间有效地检测到低出生体重婴儿的异常迹象。因此,开发的图表将提高妊娠期间胎儿风险评估的质量,并降低不良新生儿结局的风险。