Farley Joel F, Hansen Richard A, Domino Marisa E, Borse Mrudula, Mahendraratnam Nirosha, Ray Neepa, Maciejewski Matthew L
UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA.
Harrison School of Pharmacy, Auburn University, USA.
Gen Hosp Psychiatry. 2017 Mar-Apr;45:25-31. doi: 10.1016/j.genhosppsych.2016.12.001. Epub 2016 Dec 8.
Patients with serious mental illness (SMI) often have comorbid cardiometabolic conditions (CMCs) that may increase the number of prescribers involved in treatment. This study examined whether patients with SMI (depression and schizophrenia) and comorbid CMCs experience greater discontinuity of prescribing than patients with CMCs alone.
2009 Medicaid data were used to compare number and types of prescribers (primary care, cardiometabolic, psychiatric, other) in individuals with 1-3 CMCs (diabetes, hypertension, dyslipidemia) alone (n=76.451); with CMC and schizophrenia (n=6507); and with CMC and depression (n=23.510) and the degree of prescribing within a provider's area of specialty.
44%, 61%, and 71% of individuals with CMCs only, with CMCs and schizophrenia, and with CMCs and depression had medications from these classes prescribed by 5 or more providers respectively. >35% of patients with CMCs alone or CMCs and schizophrenia had prescriptions provided by 3 or more PCP providers, which increased to 49.1% for patients with CMCs and depression. In the schizophrenia cohort, 29% of antipsychotics were PCP-prescribed while psychiatrists prescribed 10%, 9%, and 9% of antihypertensive, antihyperlipidemic, and antidiabetic medications respectively.
The presence of SMI increases the number of prescribers treating individuals with CMCs. The impact of this fragmentation in medication management on health outcomes is unknown.
患有严重精神疾病(SMI)的患者通常合并有心脏代谢疾病(CMC),这可能会增加参与治疗的开处方者数量。本研究调查了患有SMI(抑郁症和精神分裂症)且合并CMC的患者与仅患有CMC的患者相比,是否经历了更大的处方中断情况。
使用2009年医疗补助数据,比较仅患有1 - 3种CMC(糖尿病、高血压、血脂异常)的个体(n = 76,451);患有CMC和精神分裂症的个体(n = 6507);以及患有CMC和抑郁症的个体(n = 23,510)的开处方者数量和类型(初级保健、心脏代谢、精神科、其他),以及在提供者专业领域内的处方程度。
仅患有CMC、患有CMC和精神分裂症、患有CMC和抑郁症的个体中,分别有44%、61%和71%的人服用这些类别的药物由5名或更多提供者开具。仅患有CMC或患有CMC和精神分裂症的患者中,超过35%的人有3名或更多初级保健提供者开具的处方,而患有CMC和抑郁症的患者这一比例增至49.1%。在精神分裂症队列中,29%的抗精神病药物由初级保健提供者开具,而精神科医生分别开具了10%、9%和9%的抗高血压、抗高血脂和抗糖尿病药物。
SMI的存在增加了治疗患有CMC个体的开处方者数量。这种药物管理碎片化对健康结果的影响尚不清楚。