Yu Yang, Zhao Weina, Li Siou, Yin Changhao
Department of Neurology, Hongqi Hospital of Mudanjiang Medical Universiy, Mudanjiang, Heilongjiang, China.
BMJ Open. 2017 Mar 8;7(3):e013432. doi: 10.1136/bmjopen-2016-013432.
Amnestic mild cognitive impairment (aMCI) and vascular mild cognitive impairment (VaMCI) comprise the 2 main types of mild cognitive impairment (MCI). The first condition generally progresses to Alzheimer's disease, whereas the second is likely to develop into vascular dementia (VD). The brain structure and function of patients with MCI differ from those of normal elderly individuals. However, whether brain structures or functions differ between these 2 MCI subtypes has not been studied. This study is designed to analyse neuroimages of brain in patients with VaMCI and aMCI using multimodality MRI (structural MRI (sMRI), functional MRI and diffusion tensor imaging (DTI)).
In this study, 80 participants diagnosed with aMCI, 80 participants diagnosed with VaMCI, and 80 age-matched, gender-matched and education-matched normal controls (NCs) will be recruited to the Hongqi Hospital of Mudanjiang Medical University, Heilongjiang, China. All participants will undergo neuroimaging and neuropsychological evaluations. The primary outcome measures will be (1) microstructural alterations revealed by multimodal MRIs, including sMRI, resting-state functional MRI and DTI; and (2) a neuropsychological evaluation, including the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Auditory Verbal Learning Test (AVLT), Memory and Executive Screening (MES), trail making test, Stroop colour naming condition and Clinical Dementia Rating (CDR) scale, to evaluate global cognition, memory function, attention, visuospatial skills, processing speed, executive function and emotion, respectively.
NCT02706210; Pre-results.
遗忘型轻度认知障碍（aMCI）和血管性轻度认知障碍（VaMCI）是轻度认知障碍（MCI）的两种主要类型。第一种情况通常会发展为阿尔茨海默病，而第二种则可能发展为血管性痴呆（VD）。MCI患者的脑结构和功能与正常老年人不同。然而，这两种MCI亚型之间的脑结构或功能是否存在差异尚未得到研究。本研究旨在使用多模态磁共振成像（结构磁共振成像（sMRI）、功能磁共振成像和扩散张量成像（DTI））分析VaMCI和aMCI患者的脑部神经影像。
在本研究中，将招募80名被诊断为aMCI的参与者、80名被诊断为VaMCI的参与者以及80名年龄、性别和教育程度相匹配的正常对照（NCs），他们将来自中国黑龙江牡丹江医学院红旗医院。所有参与者都将接受神经影像和神经心理学评估。主要结局指标将包括：（1）多模态磁共振成像揭示的微观结构改变，包括sMRI、静息态功能磁共振成像和DTI；以及（2）神经心理学评估，包括简易精神状态检查表（MMSE）、蒙特利尔认知评估量表（MoCA）、听觉词语学习测验（AVLT）、记忆与执行筛查量表（MES）、连线测验、斯特鲁普颜色命名测验和临床痴呆评定量表（CDR），分别用于评估整体认知、记忆功能、注意力、视觉空间技能、处理速度、执行功能和情绪。
NCT02706210；预结果。
