Kellesarian S V, Malignaggi V R, Kellesarian T V, Al-Kheraif A A, Alwageet M M, Malmstrom H, Romanos G E, Javed F
Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, Rochester, NY, USA.
Department of General Dentistry, Faculty of Dentistry, Universidad Santa Maria, Caracas, Venezuela.
Int J Impot Res. 2017 May;29(3):89-95. doi: 10.1038/ijir.2017.7. Epub 2017 Mar 9.
The purpose of the present study was to review systematically the association between periodontal diseases (PDs) and polycystic ovary syndrome (PCOS). To address the focused question, 'Is there a relationship between PD and PCOS?' indexed databases were searched up to October 2016 without time or language restrictions using different combinations of the following key words: PCOS, ovarian cysts, PD, periodontitis, gingival diseases and gingivitis. Letters to the Editor, commentaries, historic reviews, case-report, unpublished articles and animal/experimental studies were excluded. Seven case-control studies were included. The number of study participants ranged between 52 and 196 females aged between 15 and 45 years. In three and three studies, proinflammatory cytokines were assessed in gingival crevicular fluid and saliva samples, respectively. In one study, salivary microbes were investigated. All studies reported that a positive association exists between PD and PCOS. In conclusion, there is a positive association between PD and PCOS; however, further well-designed longitudinal controlled clinical trials are needed in this regard. It is recommended that physicians should refer patients with PCOS to oral health-care providers for comprehensive oral evaluation and treatment.
本研究的目的是系统回顾牙周疾病（PDs）与多囊卵巢综合征（PCOS）之间的关联。为回答核心问题“PD与PCOS之间是否存在关联？”，我们检索了截至2016年10月的索引数据库，检索时不受时间或语言限制，使用了以下关键词的不同组合：PCOS、卵巢囊肿、PD、牙周炎、牙龈疾病和牙龈炎。排除了致编辑信、评论、历史综述、病例报告、未发表文章以及动物/实验研究。纳入了七项病例对照研究。研究参与者为52至196名年龄在15至45岁之间的女性。在三项研究中分别评估了龈沟液中的促炎细胞因子，在另外三项研究中评估了唾液样本中的促炎细胞因子。在一项研究中调查了唾液微生物。所有研究均报告PD与PCOS之间存在正相关。总之，PD与PCOS之间存在正相关；然而，在这方面还需要进一步设计良好的纵向对照临床试验。建议医生将PCOS患者转诊至口腔保健机构进行全面的口腔评估和治疗。
