Bitonti Vincenzo, Perri Tiziana, Cigni Lorenzo, Familiari Domenico, Vazzana Giuseppe, Franco Rocco
UOC Odontostomatologia e Chirurgia Orale, AUSL Modena, 41122 Modena, Italy.
UO Ginecologia e Ostetricia Ospedale SS Annunziata, AUSL Ferrara, 44121 Ferrara, Italy.
Dent J (Basel). 2025 Apr 25;13(5):188. doi: 10.3390/dj13050188.
Periodontal disease (PD) and polycystic ovary syndrome (PCOS) are two prevalent conditions that have been independently associated with systemic inflammation and hormonal dysregulation. Emerging evidence suggests a potential bidirectional relationship between these conditions, but the nature and strength of this association remain unclear. This systematic review aimed to evaluate and synthesize the existing evidence on the association between periodontal disease and polycystic ovary syndrome, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was conducted in multiple databases, including PubMed, Scopus, and Web of Science, from 1990 to 2025. Studies investigating the association between PD and PCOS in terms of prevalence, severity, and shared pathophysiological mechanisms were included. Two independent reviewers screened studies for eligibility, extracted data, and assessed methodological quality using validated tools. Discrepancies were resolved through consensus. Meta-analysis was conducted where appropriate. A total of nine studies were included. Most studies reported a higher prevalence and severity of periodontal disease among women with PCOS compared to controls. Shared mechanisms, including systemic inflammation, insulin resistance, and hormonal dysregulation, were frequently proposed as underlying factors. However, heterogeneity in study designs, diagnostic criteria, and confounding adjustments limited the comparability of findings. This systematic review supports a potential association between periodontal disease and polycystic ovary syndrome, likely mediated by common inflammatory and metabolic pathways. However, the evidence is limited by heterogeneity and methodological biases. Further well-designed longitudinal studies are needed to clarify causal relationships and explore the clinical implications of integrating periodontal health management into PCOS care.
牙周病（PD）和多囊卵巢综合征（PCOS）是两种常见病症，它们各自都与全身炎症和激素失调有关。新出现的证据表明这两种病症之间可能存在双向关系，但这种关联的性质和强度仍不明确。本系统评价旨在按照系统评价和Meta分析的首选报告项目（PRISMA）指南，评估和综合关于牙周病与多囊卵巢综合征之间关联的现有证据。在多个数据库中进行了全面的文献检索，包括PubMed、Scopus和Web of Science，检索时间跨度为1990年至2025年。纳入了从患病率、严重程度和共同病理生理机制方面研究PD与PCOS之间关联的研究。两名独立评审员筛选研究的 eligibility，提取数据，并使用经过验证的工具评估方法学质量。通过共识解决分歧。在适当情况下进行Meta分析。共纳入9项研究。大多数研究报告称，与对照组相比，PCOS女性中牙周病的患病率和严重程度更高。包括全身炎症、胰岛素抵抗和激素失调在内的共同机制经常被认为是潜在因素。然而，研究设计、诊断标准和混杂因素调整方面的异质性限制了研究结果的可比性。本系统评价支持牙周病与多囊卵巢综合征之间可能存在关联，可能由共同的炎症和代谢途径介导。然而，证据受到异质性和方法学偏倚的限制。需要进一步设计良好的纵向研究来阐明因果关系，并探索将牙周健康管理纳入PCOS护理的临床意义。
