Department of Internal Medicine, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Department of Nephrology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Hypertens Res. 2017 Aug;40(8):758-764. doi: 10.1038/hr.2017.36. Epub 2017 Mar 9.
This study aimed to examine the relationship between the ratio of monocyte frequency to high-density lipoprotein (HDL) cholesterol level (the monocyte/HDL ratio (MHR)) and asymptomatic organ damage (AOD) in primary hypertension (PHT). A total of 366 participants were enrolled in the study, including 275 cases currently being followed up after a diagnosis of PHT in our clinic and 91 healthy volunteers. The MHR was higher in patients with PHT than in individuals in the control group. In the PHT group, the MHR was higher in patients with AOD (AOD+) than in patients without AOD (AOD-). In the correlation analyses performed in the PHT group, there were positive correlations between the MHR and the following AOD indicators: carotid intima media thickness, left ventricular mass index, urinary protein levels and urinary albumin levels. In a multivariate linear regression analysis, the MHR was found to be an independent risk factor associated with these indicators of AOD. In conclusion, our study shows that MHR is associated with AOD in patients with PHT.
本研究旨在探讨单核细胞频率与高密度脂蛋白（HDL）胆固醇水平之比（单核细胞/高密度脂蛋白比值（MHR））与原发性高血压（PHT）无症状器官损害（AOD）之间的关系。共有 366 名参与者入组，包括 275 名在我院确诊为 PHT 后正在接受随访的患者和 91 名健康志愿者。与对照组相比，PHT 患者的 MHR 更高。在 PHT 组中，AOD 阳性（AOD+）患者的 MHR 高于 AOD 阴性（AOD-）患者。在 PHT 组的相关性分析中，MHR 与颈动脉内膜中层厚度、左心室质量指数、尿蛋白水平和尿白蛋白水平等 AOD 指标呈正相关。在多变量线性回归分析中，MHR 是与这些 AOD 指标相关的独立危险因素。总之，本研究表明，MHR 与 PHT 患者的 AOD 相关。
