系统性红斑狼疮患者单核细胞与高密度脂蛋白胆固醇比值与颈动脉内膜中层厚度的关联
Association of monocyte to high-density lipoprotein cholesterol ratio with carotid artery intima-media thickness in patients with systemic lupus erythematosus.
作者信息
Wang Qian, Meng Yan, Cao Wenyan, Du Wenjing, Liu Yumei, Yan Yi, Luo Li, Ma Xiumin
机构信息
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830011, PR China.
Clinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, PR China.
出版信息
Biomark Med. 2018 Apr;12(4):359-364. doi: 10.2217/bmm-2016-0362. Epub 2018 Mar 23.
AIM
The purpose of this study was to evaluate the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and carotid atherosclerostic plaque in patients with systemic lupus erythematosus (SLE).
METHODS
A total of 214 SLE patients were divided into two groups according to the results of ultrasonic examination: carotid arterial atherosclerotic plaque groups and noncarotid arterial atherosclerosis groups.
RESULTS
The values of monocyte to high-density lipoprotein-cholesterol ratio (MHR) increase in carotid arterial atherosclerotic plaque groups compared with noncarotid arterial atherosclerosis groups (0.32 ± 0.18 vs 0.26 ± 0.15; p = 0.015). There was a significant correlation between MHR and carotid artery intima-media thickness (r = 0.228; p = 0.001) in patients with SLE.
CONCLUSION
Our study suggests that the values of MHR could be a marker to assess carotid artery intima-media thickness in patients with SLE.
目的
本研究旨在评估系统性红斑狼疮（SLE）患者单核细胞与高密度脂蛋白胆固醇比值（MHR）与颈动脉粥样硬化斑块之间的关系。
方法
根据超声检查结果，将214例SLE患者分为两组：颈动脉粥样硬化斑块组和非颈动脉粥样硬化组。
结果
与非颈动脉粥样硬化组相比，颈动脉粥样硬化斑块组的单核细胞与高密度脂蛋白胆固醇比值（MHR）升高（0.32±0.18 vs 0.26±0.15；p = 0.015）。SLE患者的MHR与颈动脉内膜中层厚度之间存在显著相关性（r = 0.228；p = 0.001）。
结论
我们的研究表明，MHR值可能是评估SLE患者颈动脉内膜中层厚度的一个指标。
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